Results 41 to 50 of about 173,284 (257)

The Primacy of Magnitude in Low-Rank Adaptation

CoRR
Low-Rank Adaptation (LoRA) offers a parameter-efficient paradigm for tuning large models. While recent spectral initialization methods improve convergence and performance over the naive "Noise & Zeros" scheme, their extra computational and storage overhead undermines efficiency. In this paper, we establish update magnitude as the fundamental driver
Zicheng Zhang, Haoran Li 0027, Yifeng Zhang, Guoqiang Gong, Jiaxing Wang, Pengzhang Liu, Qixia Jiang, Junxing Hu   +7 more
openaire   +2 more sources

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Supporting evidence-based adaptation decision-making in Queensland: a synthesis of climate change adaptation research [PDF]

, 2013
This research synthesis provides policy-makers and practitioners with an understanding of the building blocks for effective adaptation decision-making, as evidenced through the NCCARF research program.
Jennifer Cane
core  

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Adapting Regularized Low-Rank Models for Parallel Architectures [PDF]

SIAM Journal on Scientific Computing, 2019
We introduce a reformulation of regularized low-rank recovery models to take advantage of GPU, multiple CPU, and hybridized architectures. Low-rank recovery often involves nuclear-norm minimization through iterative thresholding of singular values. These models are slow to fit and difficult to parallelize because of their dependence on computing a ...
Derek Driggs, Stephen Becker, Aleksandr Y. Aravkin   +2 more
openaire   +3 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Climate change adaptation in the boardroom [PDF]

, 2013
Climate adaptation is recognised by many of the world’s largest businesses as a global risk and one that requires critical attention. The World Economic Forum’s 2013 Global Risks Perception Survey, identified the ‘failure of climate change adaptation and
Mark Baker-Jones, Gareth Johnston, Donovan Burton   +2 more
core  

GoRA: Gradient-driven Adaptive Low Rank Adaptation

CoRR
NeurIPS ...
He, Haonan, Ye, Peng, Ren, Yuchen, Yuan, Yuan, Zhou, Luyang, Ju, Shucun, Chen, Lei   +6 more
openaire   +2 more sources

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source