Results 121 to 130 of about 9,171,861 (296)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Improved initial approximation for errors-in-variables system identification
Errors-in-variables system identification can be posed and solved as a Hankel structured low-rank approximation problem. In this paper different estimates based on suboptimal low-rank approximations are considered.
Usevich, Konstantin
core +1 more source
Gamma norm minimization based image denoising algorithm
Tongxin xuebao, 2020 Focusing on the issue of rather poor denoising performance of the traditional kernel norm minimization based method caused by the biased approximation of kernel norm to rank function,based on the low-rank theory,a gamma norm minimization based image ...
Hongyan WANG +3 more
doaj +2 more sources
Hyperspectral Image Denoising Based on Nonconvex Low Rank Matrix Approximation and TotalVariation Regularization [PDF]
Jisuanji kexue, 2021 TAO Xing-peng, XU Hong-hui, ZHENG Jian-wei, CHEN Wan-jun
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
IEEE Journal of Selected Topics in Applied Earth Observations and Remote SensingThe structure information of hyperspectral image (HSI) is well-characterized by tensors, surpassing the capabilities of traditional compressive sensing reconstruction models based on vectors and matrices.
Xinwei Wan +4 more
doaj +1 more source
Worst-case low-rank approximations
CoRRReal-world data in health, economics, and environmental sciences are often collected across heterogeneous domains (such as hospitals, regions, or time periods). In such settings, distributional shifts can make standard PCA unreliable, in that, for example, the leading principal components may explain substantially less variance in unseen domains than ...
Anya Fries +3 more
openaire +3 more sources
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Low Rank Circulant Approximation
, 2008 Partially due to the fact that the empirical data collected in practice by devices with finite bandwidth often neither maintain the specified structure nor induce a certain desired rank, structured low rank approximation arises in many important ...
Moody Chu And +1 more
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