Results 61 to 70 of about 1,119,437 (280)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Stage-Wise Simulation for Operational Stability Evaluation of Seasonal Heat Storage in Abandoned Coal Mines

Energies
The development of coal resources has created a large number of underground mined-out spaces, which can be utilized for cross-seasonal thermal storage through underground reservoirs to achieve seasonal heat storage.
Wenying Tang, Jiawei Tang, Qiang Guo, Haiqin Zhang, Changhao Feng, Xiaolin He, Zixu Hu, Xi Wu   +7 more
doaj   +1 more source

Low-Resource Semantic Role Labeling [PDF]

Proceedings of the 52nd Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers), 2014
We explore the extent to which highresource manual annotations such as treebanks are necessary for the task of semantic role labeling (SRL). We examine how performance changes without syntactic supervision, comparing both joint and pipelined methods to induce latent syntax.
Matthew R. Gormley, Margaret Mitchell, Benjamin Van Durme, Mark Dredze   +3 more
openaire   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Performance Evaluation of Heat Storage in a Full Operation Cycle of Cross-Seasonal Thermal Energy Storage Systems in Coal Mine Underground Reservoirs

Applied Sciences
Coal mining has generated a large amount of underground space, which has traditionally been reused mostly as mine wastewater storage. Given the excellent thermal insulation properties of these mine reservoirs, their potential for seasonal energy storage ...
Wenying Tang, Jiawei Tang, Qiang Guo, Haiqin Zhang, Changhao Feng, Yilong Yuan, Xiaolin He, Zixu Hu   +7 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Production of antibacterial bacterial cellulose through co-fermentation using Lactiplantibacillus plantarum and Pediococcus pentosaceus enhanced rice soaking wastewater

Industrial Crops and Products
Bacterial cellulose (BC) exhibits a range of exceptional properties, including outstanding purity, superior tensile strength, rapid moisture recovery rate, and excellent biocompatibility, giving it broad application potential.
Jianfen Zhang, Feng Peng, Hong Chen, Guangfa Xie   +3 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Surface damage reduction effect of ultra-high working face in Shangwan coal mine

Scientific Reports
Green mining is the basic background of high-quality mining, and source reduction is the most important part, among which the optimization of working face height and length is the most active.
L. I. U. Xinjie, Yang Yingming, Zhao Yongqiang, WANG Xiaolong, Liu Gang, Xu Zhuhe   +5 more
doaj   +1 more source