Results 81 to 90 of about 11,850,628 (306)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Community-informed trial design and implementation to optimize recruitment and retention in low-income settings: lessons from rheumatic heart disease trials in Uganda

Frontiers in Cardiovascular Medicine
Research teams undertaking randomized clinical trials in low-and middle-income countries frequently encounter significant challenges, including limited infrastructure, cultural barriers to trust, and limited resources.
Juliet Alepere, Susan Akullo, Pamela Okwir Apio, Brenda Atim, Andrea Beaton, Andrea Beaton, Anneke Grobler, Anneke Grobler, Samalie Kitooleko, Haddy Nalubwama, Emma Ndagire, Emma Ndagire, Emmy Okello, Emmy Okello, Isaac Otim Omara, Jafes Pulle, Joselyn Rwebembera, Craig Sable, Craig Sable, Amy Scheel, Alison Spaziani, Andrew Steer, Andrew Steer, Rachel Sarnacki   +23 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

LSAFJiu: A Low-Resource Algorithm for Tibetan Jiu Chess Based on Long Sequence Action Forecasting

Tsinghua Science and Technology
Tibetan Jiu Chess, the national intangible cultural heritage of China, involves complex gameplay with both layout and battle stages, presenting a vast action space. Deep learning effectiveness is often limited by computational and data constraints.
Xiali Li, Chen Su, Junzhi Yu, Xiaoyu Fan, Junxue Dai   +4 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Pacific Concerns Resource Center bulletin

, 1985
"A publication of the Pacific Concerns Resource Center, in support of the Nuclear Free and Independent Pacific Movement.
Pacific Concerns Resource Center
core   +1 more source

Production of antibacterial bacterial cellulose through co-fermentation using Lactiplantibacillus plantarum and Pediococcus pentosaceus enhanced rice soaking wastewater

Industrial Crops and Products
Bacterial cellulose (BC) exhibits a range of exceptional properties, including outstanding purity, superior tensile strength, rapid moisture recovery rate, and excellent biocompatibility, giving it broad application potential.
Jianfen Zhang, Feng Peng, Hong Chen, Guangfa Xie   +3 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Resource News issue: summer 1999 [PDF]

, 1999
The summer 1999 issue of Resource News, which was a community newsletter from the Child Care Resource and Referral office of Washington County ...
Washington County Child Care Resource and Referral (Or.)
core   +1 more source

AIDS Resource Center commercial with Kim Dawson

, 1989
Video footage from the Resource Center LGBT Collection. The video is an AIDS Resource Center commercial with talent agent Kim Dawson.
AIDS Resource Center
core