Results 91 to 100 of about 11,850,628 (306)

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Vertical zoning characteristics and genesis mechanism of groundwater hydrochemistry: a case study of Xinjie Mining Area

Meitan kexue jishu
Mine water, as the main potential water supply source for coal mine sites, has a good potential for comprehensive reuse. However, the complex and diverse physical and chemical reactions between the coal seam roof-filling aquifers and the surrounding ...
Xudong WANG, Zuyu YAN, Qiang GUO, Suo ZHANG, Jiawei TANG, Yutian HU, Xiaoqing LIU, Jingfeng LI   +7 more
doaj   +1 more source

AIDS Resource Center commercial with Dan Rizzie

, 1989
Video footage from the Resource Center LGBT Collection. The video is an AIDS Resource Center commercial with artist Dan Rizzie.
AIDS Resource Center
core  

Meta Learning for Low-Resource Molecular Optimization

, 2021
The goal of molecular optimization (MO) is to discover molecules that acquire improved pharmaceutical properties over a known starting molecule. Despite many recent successes of new approaches for MO, these methods were typically developed for particular
Zheng, Shuangjia, Wang, Jiahao, Chen, Jianwen, Yang, Yuedong   +3 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Enhanced removal of refractory organic pollutants from high-salinity mining wastewater by E-peroxone process

Meitan xuebao
High-salinity mining wastewater is produced in the process of zero discharge. Due to its complex composition and high organic concentration, its treatment has become a worldwide problem.
Anni CHEN, Qiang GUO, Yanying YIN, Jingfeng LI, Yixiang BAO, Min WU, Shizuo YI, Jianbing WANG, Huijiao WANG   +8 more
doaj   +1 more source

AIDS Resource Center commercial with Randy Moore

, 1989
Video footage from the Resource Center LGBT Collection. The video is an AIDS Resource Center commercial with Randy Moore and his family.
AIDS Resource Center
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Distribution characteristics and genesis mechanisms of fluoride ions in groundwater in mining areas: a case study of Xinjie Taigemiao Mining Area

Meitan kexue jishu
Groundwater in mining areas serves as a critical water source for production, domestic use, and ecological sustainability, with its quality directly impacting regional sustainable development.
Jiawei TANG, Xudong WANG, Qiang GUO, Zuyu YAN, Zhaofeng LIU, Ruibing YAN, Ziwei WANG, Yixiang BAO, Jingfeng LI, Anmin HE   +9 more
doaj   +1 more source