Results 51 to 60 of about 197,184 (256)

Multi-Objective Optimisation of Skylight Design Parameters for a Low-rise Building in the Tropics

International Journal of Technology
Skylight is an effective strategy for maximising daylight penetration while minimising electrical lighting energy demand in buildings. However, in tropical climate regions, skylight can be problematic due to the risk of excessive sunlight. This study
Dinta Wijaya, Sentagi Sesotya Utami, Rizki Armanto Mangkuto   +2 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Seismic response of low-rise buildings

Bulletin of the New Zealand Society for Earthquake Engineering, 1986
The results of an investigation into the dynamic response of several low-rise structures are reported. The main parameters studied were the effect of variations in the form of the hysteresis loop exhibited by the inelastic members and of differing types of earthquake accelerograms.
P. J. Moss, A. J. Carr, A. H. Buchanan
openaire   +2 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

The Application of Rainwater as Architectural Design Elements For Green Technology Solution In Low Rise Office Building

International Journal of Built Environment and Sustainability, 2018
Performance of workers in terms of productivity level is determined by many related factors including a comfortable work space. Nevertheless, the discussion on the condition of work space environment namely in low rise office buildings and its related ...
Alice Sabrina Ismail, Nur Syahirah Sa’ezan   +1 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Analisa Perbandingan Penggunaan Bekisting Semi Konvensional Dengan Bekisting Sistem Table Form Pada Konstruksi Gedung Bertingkat

Jurnal Teknik ITS, 2012
Pekerjaan bekisting memberikan kontribusi yang cukup besar dalam hal proporsi biaya pekerjaan beton. Produktifitas dan siklus dari pekerjaan bekisting juga mempengaruhi waktu pekerjaan beton. Oleh karena itu, dalam merencanakan pekerjaan bekisting  harus
Yevi Novi Dwi Saraswati, Retno Indryani
doaj