Results 91 to 100 of about 17,861 (298)

A Non‐Canonical Core Transcriptional Regulatory Circuit Orchestrates Chromatin Reprogramming to Drive Osimertinib Resistance in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
A non‐canonical core transcriptional regulatory circuit, composed of ID3, SMAD3, and NR2F2, drives Osimertinib resistance in non‐small cell lung cancer through super‐enhancer‐mediated activation of EPAS1, which couples neuroendocrine differentiation with ferroptosis evasion.
Aochu Liu, Zhenguo Liu, Lizhen Jiang, Andong Huang, Xinqing Lin, Xinyue Li, Bingyuan Liu, Shiwen Hu, Qiang Pan, Junjun Huang, Liyuan Yin, Liling Jiang, Wei Yi, Wenjun Mao, Yueyuan Zheng, Xianping Shi   +15 more
wiley   +1 more source

Predicted Versus Actual Savings for a Low-Rise Multifamily Retrofit in Boulder, Colorado [PDF]

, 2013
To determine the most cost-effective methods of improving buildings, accurate analysis and prediction of the energy use of existing buildings is essential.
Arena, L., Williamson, J.
core   +1 more source

Lesion Site‐Targeted Microspheres Modulate Nav1.7‐Related Signaling for Osteoarthritis Treatment

Advanced Science, EarlyView.
Cartilage‐targeted carbamazepine‐loaded WYRGRL‐modified composite microspheres (CBZ/WCOM) anchor to exposed type II collagen in osteoarthritic lesions and release carbamazepine under acidic conditions. This bind‐then‐release platform modulates Nav1.7‐related sodium signaling, Na⁺/Ca²⁺ exchanger‐associated Ca2+ dynamics, and heat shock protein 70 ...
Cheng Chen, Jiaying Li, Jinjin Ma, Xiaonan Yuan, Yao Xiao, Yang Zhang, Yuan Chen, Hao Jiang, Hui He, Jie Hu, Qianglong Chen, Jinniu Zhang, Bin Li, Yun Zhou, Fengxuan Han, Yong Wang   +15 more
wiley   +1 more source

Daylighting Strategies for Low-Rise Residential Buildings Through Analysis of Architectural Design Parameters

Architecture
Daylighting is essential in residential building design because it influences energy efficiency and visual comfort while also supporting occupants’ health and overall well-being. Adequate natural light exposure aids circadian regulation and psychological
Kamaraj Kalaimathy, Sudha Gopalakrishnan, Radhakrishnan Shanthi Priya, Chandrasekaran Selvam, Ramalingam Senthil   +4 more
doaj   +1 more source

Quality assessment of urban areas based on neural network modeling and GIS

E3S Web of Conferences, 2018
In this article the authors carry out the research of the urban development areas structure and propose the system of its characteristics on the basis of sector affiliation of the municipal economy.
Popova Olga, Glebova Julia, Pustovgar Andrey   +2 more
doaj   +1 more source

Atomic‐Level CuOx‐CoOx‐Pd Interfacial Engineering Enables Hierarchical Synergy for High‐Efficiency ORR Pathways and Boosted Power Output in Alkaline Fuel Cells

Advanced Science, EarlyView.
Atomically dispersed CuOx (CPCu‐1) forms isolated Cu–Ov sites that enable defect‐mediated O2 activation and fast electron/proton transfer via interfacial synergy. In contrast, thick CuOx clusters (CPCu‐10) promote a surface‐adsorption‐controlled pathway with intermediate accumulation, highlighting a mechanism switch from interfacial activation to ...
Yang‐Yang Hsu, Ching‐Hua Fan, Kuan‐Wen Wang, Kuang‐Kuo Wang, Nozomu Hiraoka, Hirofumi Ishii, Ting‐Shan Chan, Po‐Chun Chen, Tsan‐Yao Chen   +8 more
wiley   +1 more source

Facing the growing problem of the electric power consumption in Egyptian residential building using building performance simulation program

, 2013
Egypt has been experiencing recurrent power cuts especially at the summer, with the problem being made worse by the extra demands placed on the electrical grid by the advent of the holy month of Ramadan.
Tuohy, Paul Gerard, Elharidi, Aly Mohamed Aly Hassan, Teamah, M.   +2 more
core  

Dynamic Single‐Binding Event Profiling With on‐Chip Microlenses for Wash‐Free Digital Biosensing

Advanced Science, EarlyView.
A microlens‐enhanced platform enables real‐time tracking and digital counting of single‐binding events using conventional bright‐field microscopy. Amplified scattering signals from gold nanoparticle labels and kinetic signature analysis allow wash‐free discrimination between specific and nonspecific interactions, while providing kinetic and mechanistic
Tingting Zhan, Lianyu Lu, Guoqiang Gu, Pengcheng Zhang, Jienan Shen, Xiaotian Tan, Wei Ye, Shi Hu, Yi Zhang, Hao Yu, Shaoqin Liu, Hairong Zheng, Hui Yang   +12 more
wiley   +1 more source

Comprehensive Evaluation of Carbon Emissions for the Development of High-Rise Residential Building

Buildings, 2018
Despite the fact that many novel initiatives have been put forward to reduce the carbon emissions of buildings, there is still a lack of comprehensive investigation in analyzing a buildings’ life cycle greenhouse gas (GHG) emissions, especially in ...
Stephen Y. C. Yim, S. Thomas Ng, M. U. Hossain, James M. W. Wong   +3 more
doaj   +1 more source

Maintenance of high-rise residential buildings

, 2018
Purpose: Preventive maintenance is an effective maintenance strategy to ensure the constant and efficient usage of building systems and their components.
Chua, Shirley Jin Lin, Cheong Peng Au-Yong, Shirley Jin Lin Chua, Au-Yong, Cheong Peng, Azlan Shah Ali, Zubbir, Najilah, Ali, Azlan Shah, Najilah Bt Zubbir   +7 more
core   +1 more source