Results 71 to 80 of about 17,861 (298)

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

Cost analysis and feasibility of green building adaptation in low-rise residential housing: Evidence from Türkiye

Journal of Design for Resilience in Architecture and Planning
This study evaluates the cost implications of green building practices in low-rise residential housing by analyzing three sample houses in Kayseri, Türkiye.
Merve Bıyıklı Hasözhan, Zübeyde Özlem Parlak Biçer, Nurbanu Şahin   +2 more
doaj   +1 more source

Review of low-carbon refurbishment solutions for residential buildings with particular reference to multi-story buildings in Hong Kong

, 2017
Highlight\ud \ud - This paper reviews the low-carbon refurbishment solutions for high-rise residential buildings in a sub-tropical climate.\ud \ud - Of the 88 identified sustainable refurbishment approaches, 39 are relevant to Hong Kong's climatic ...
Li, Jun, Skitmore, Martin, Li, J, Skitmore, RM, Ng, S. Thomas, Ng, TST   +5 more
core   +1 more source

Microglia‐Targeted Biomimetic Tetrahedral Framework Nucleic Acid Nanovesicles for Synergistic Treatment of Sepsis‐Associated Encephalopathy

Advanced Science, EarlyView.
Sepsis‐associated encephalopathy (SAE) lacks effective therapies. We developed ME@FDsi, a biomimetic nanodrug using a tetrahedral framework nucleic acid to deliver disulfiram and siTNFα. It crosses the blood‐brain barrier, targets M1 microglia, inhibits pyroptosis and inflammation, and scavenges ROS.
Huimin Shi, Qiuxia Gao, Wenying Wang, Bin Li, Yukun Chen, Zhijun Yao, Yujie Li, Junrui Li, Na Li, Gong Gu, Zhimin Hou, Mengyuan Yang, Ruilin Zhang, Hongju Yang, Yuhui Liao, Hongyi Lei   +15 more
wiley   +1 more source

Structural Risk Assessment and Mitigation for Low- to Mid-Rise Residential Buildings in China

Frontiers in Built Environment, 2017
China has experienced major earthquakes recently. The 2014 Ludian earthquake struck Ludian County, Yunnan, (Mw = 6.1) on 3 August, 2014. On April 20th 2013, Ya’an earthquake (Mw = 6.9), on April 14th 2010, Qinghai earthquake (Mw = 7.1), on July 9th 2009,
Kasim A. Korkmaz
doaj   +1 more source

Addressing social isolation in high-rise residential buildings in Kuala Lumpur [PDF]

As the urban population grows, the construction of high-rise buildings has increased, often prioritizing functionality and aesthetics over community interactions.
Mohd Noor, Mohd Zairul, Lee, Nur Irdina, Ma’rof, Aini Azeqa   +2 more
core   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Generative Design System For Low-Rise Residential Buildings

, 2018
The generative design is one of the types of computer-aided designs in which the architect’s role is to create a system of scripts and algorithms which enables one to automatically create the design of buildings through the pre-established suite of algorithms. The article considers the practical development of the system based on the author's algorithm
openaire   +1 more source

tBid‐Mediated Genetic Ablation of Connective Tissue Cells Reveals Their Key Regulatory Function During Limb Regeneration in Axolotls

Advanced Science, EarlyView.
We establish a tBid‐mediated cell ablation system in axolotls, achieve rapid and efficient ablation of multiple cell types, including muscle stem cell, spinal cord cell, and connective tissue (CT) cells. We investigate the role of CT using tBid‐mediated CT ablation and identify its essential role for limb development and regeneration.
Yan Hu, Weimin Feng, Zitian He, Jiayi Zeng, Jingyi Tang, Shulin Li, Tongbo Yu, Sulei Fu, Hui Ma, Binbin Lu, Yanmei Liu, Ji‐Feng Fei   +11 more
wiley   +1 more source

Radiation‐Resistant Kr‐Selective MOF With Record Kr/Xe Selectivity at Elevated Pressure

Advanced Science, EarlyView.
ABSTRACT The separation of Kr/Xe from spent nuclear fuel off‐gas is critical, yet most current adsorbents exhibit Xe‐Kr co‐adsorption under elevated pressures, posing challenges for industrial pressure swing adsorption processes. Herein, we present and evaluate a metal‐organic framework, CALF‐20M‐w, engineered for molecular sieving separation of Kr/Xe ...
Qihang Tian, Yinhui Li, Qingkuan Meng, Shizhen Liu, Yongzheng Wang, Bin Chen, Heping Ma   +6 more
wiley   +1 more source