Results 51 to 60 of about 16,113,337 (300)

Impact behaviour of an innovative trapezoidal composite corrugated core sandwich structure under low-velocity impact: an experimental and numerical study [PDF]

, 2020
Composite core sandwich structures have been extensively used in aerospace, marine and automotive applications. A few configurations of composite cores have been used in manufacturing sandwich structures for many years.
Zangana, Sartip
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Study of the behavior of damaged low-velocity impact carbon/epoxy/AL2024-T3 hybrid laminates

Discover Materials
Aluminium and layered composite structures currently play a crucial role in the aviation sector. These structures may be susceptible to inadvertent impacts from several sources.
Fatima Zohra Daouache, Amin Houari, Mourad Lounis, Lecheb Samir, Salah Amroune, Kouider Madani, Barhm Mohamad, Mohamed Belhouari   +7 more
doaj   +1 more source

Fiber Metal Laminates under Low Velocity Impact: An Experimental / Analytical Approach [PDF]

علوم و تکنولوژی پلیمر, 2012
Fiber/ metal laminates (FMLs) are hybrid composites consisting of alternating thin layers of metal sheets and fiber reinforced epoxy laminates. In this study, the effect of fiber orientation on impact properties of FML plates is investigated both ...
mostafa sabzikar borojerdi, soheil daryoushi, Mojtaba sedighi   +2 more
doaj   +1 more source

Effect of repair parameters on composite plates under low velocity impact

European Mechanical Science, 2022
In this study, the impact behavior of patch-repaired layered composite plates under low velocity impact loads was numerically investigated. For this purpose, layered composite plates with holes with different geometries in the middle were repaired with ...
Mete Onur Kaman, Mustafa Albayrak, Mustafa Gür   +2 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Low velocity impact response of CFRP and Al2024-T3 helicopter blade

International Journal of Aeronautics and Astronautics
A high level of safety is demanded in response to the foreign object damage (FOD) problem frequently encountered in aviation. For this reason, in this study, the effect of stone impact on a helicopter blade performed within the scope of FOD is ...
Sakine Kurtar, Gamze Yaman, Dilara Nur Bektaş, Seda Nur Özsunar, Mesut Uyaner   +4 more
doaj   +1 more source