Results 71 to 80 of about 956,942 (290)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Modelling Low Velocity Impact on Structural Composites

IOP Conference Series: Materials Science and Engineering, 2020
Abstract Insertion of composite materials into next generation vehicles requires an understanding of their response over the range of relevant loading conditions encountered in the field. This paper focuses on modelling the low velocity, high energy impact on structural composite materials.
M Yeager, S E Boyd, J M Staniszewski, B A Patterson, D B Knorr, T A Bogetti   +5 more
openaire   +1 more source

Development of methologies to study the damage tolerance of aeronautical and aerospace composite structures [PDF]

, 2008
Mechanics of Advanced Materials research group (Department of Continuum Mechanics and Structural Analysis) of the University Carlos III of Madrid (Spain) offers their experience in the analysis and modelization of high and low velocity impact behaviour ...
Barbero Pozuelo, Enrique, Sánchez Sáez, Sonia   +1 more
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Damage accumulation and failure mechanism of glass/epoxy composite laminates subjected to repeated low velocity impacts

e-Polymers, 2023
In this work, the damage accumulation and failure mechanism of glass fiber-reinforced epoxy composite laminates under repeated low velocity impacts were studied considering the influence of stacking sequence.
Li Hao, Yu Zhaogang, Liu Kun, Tao Zhen, Zhang Jiangtao   +4 more
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Enhanced Infrared Image Processing for Impacted Carbon/Glass Fiber-Reinforced Composite Evaluation

Sensors, 2017
In this paper, an infrared pre-processing modality is presented. Different from a signal smoothing modality which only uses a polynomial fitting as the pre-processing method, the presented modality instead takes into account the low-order derivatives to ...
Hai Zhang, Nicolas P. Avdelidis, Ahmad Osman, Clemente Ibarra-Castanedo, Stefano Sfarra, Henrique Fernandes, Theodore E. Matikas, Xavier P. V. Maldague   +7 more
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

A Novel Spring-Actuated Low-Velocity Impact Testing Setup

Applied System Innovation
Evaluating the behavior of materials and their response under low-velocity dynamic impact (less than 30 m/s) is a challenging task in various industries.
Mesut Kucuk, Moheldeen Hejazi, Ali Sari
doaj   +1 more source

Characterization of Low-Velocity Impact Damage in Asymmetric Composite Shells [PDF]

Journal of Applied and Computational Mechanics
Based on numerical modelling, this study investigates asymmetric semicylindrical composite laminate shells' damage characteristics under low-velocity impact loads.
Luis Ferreira, Carlos Coelho, Paulo Reis
doaj   +1 more source