Dysregulation of the PATZ1/CTCF Balance Silences ZBTB20 to Drive Melanoma Progression
This study uncovers a new oncogenic mechanism in melanoma. The transcription factor PATZ1 competes with the architectural protein CTCF for DNA binding, thereby disrupting a specific chromatin loop and silencing the tumor suppressor ZBTB20. This event unleashes the pro‐tumorigenic PMEPA1‐p38‐STAT1 signaling axis, promoting cancer progression.
Chaowei Deng +8 more
wiley +1 more source
Robot Assisted Low Anterior Resection for Obese Rectal Cancer Patients: A Single-center Analysis of Short-term Outcomes. [PDF]
Teraishi F +8 more
europepmc +1 more source
Lymphoid‐Tissue‐on‐Chip Recapitulates Human Antibody Responses In Vitro
The presented lymphoid‐tissue‐on‐chip system allows culture of primary human tonsil cells at organotypic high density under perfusion for up to 4 weeks, emulates immune response to soluble vaccines and vaccination via peripheral antigen‐presenting cells and represents a useful tool to assess cellular interactions during homeostasis, immune responses ...
Claudia Teufel +15 more
wiley +1 more source
Status quo of management of low anterior resection syndrome
HOU Yinmeng, LI Shuo, WANG Ling
doaj
Effect of psyllium husk on low anterior resection syndrome after rectal cancer surgery-a pilot prospective cohort study. [PDF]
Holte SS +6 more
europepmc +1 more source
Liquid Metal Nanotransformers for Drug‐Resistant Pan‐Cancer Therapy in Patient‐Derived Organoids
Pan‐cancer therapies are severely limited in drug‐resistance patients due to genetic mutations and other factors, resulting in poor therapeutic outcomes and constrained clinical benefit. Liquid metal nanotransformers, a new class of shape‐transformable nanomaterials capable of dramatic morphological changes, offer a promising physical strategy to ...
Xiaojie Yuan +19 more
wiley +1 more source
Bowel perforation following transanal irrigation in low anterior resection syndrome. [PDF]
Sami AN, Perdawood SK.
europepmc +1 more source
A cascade‐responsive MXene@Cu‐MOF/GelMA hydrogel is engineered as a “skeleton–backpack” platform for extensive tracheal repair. The MXene framework scavenges postoperative ROS and converts NIR light into mild hyperthermia, while the Cu‐MOF component provides pH/NIR‐responsive Cu2+ dosing for infection control, angiogenesis, and chondrogenesis.
Liang Guo +8 more
wiley +1 more source
Prevalence and clinical significance of evacuation disorders in patients with low anterior resection syndrome. [PDF]
Homma Y +4 more
europepmc +1 more source

