Results 161 to 170 of about 9,181,709 (294)

Targeting Tex10 Overcomes Oxaliplatin Resistance by Competitively Disrupting the Non‐Canonical BAF Complex in Colorectal Cancer

Advanced Science, EarlyView.
This study reveals that Tex10 drives oxaliplatin resistance in colorectal cancer by competitively binding BRD9 to disrupt the ncBAF complex, thereby suppressing AMBRA1 transcription and ULK1‐mediated autophagy. Gemcitabine is identified as a direct Tex10 inhibitor that restores autophagy and overcomes resistance.
Ping Xu, Jie Huang, Xiaojin Gao, Lin Deng, Yanheng Deng, Denglu Wang, Chunlei Yu, Yunxiang Zhang, Jingdong Li, Xiaocong Xiang   +9 more
wiley   +1 more source

Bidirectional longitudinal associations between low anterior resection syndrome and stigma in patients with postoperative LARS: a cross-lagged panel study. [PDF]

Front Public Health
Hu X, Yin Q, Cao M, Liang C, Yang H.
europepmc   +1 more source

Tumor‐Derived Exosomal circAP2B1 Induces M2 Macrophage Polarization by Enhancing Mitochondrial Homeostasis to Promote Esophageal Squamous Cell Carcinoma Progression

Advanced Science, EarlyView.
ESCC‐derived exosomal circAP2B1 promotes tumor progression by reprogramming mitochondrial metabolism via the ESRRA/KPNA1/MFN2 axis to induce M2 polarization of macrophages. ABSTRACT Esophageal squamous cell carcinoma (ESCC) remodels the immunosuppressive tumor microenvironment via exosome‐mediated intercellular communication.
Yiru Wang, Gang Feng, Youyu Wang, Ruihao Liang, Haixia Pan, Kai Lei   +5 more
wiley   +1 more source

Beyond surgical showcase: workflow continuity and exploratory AI-oriented video interpretability of robotic low anterior resection videos on YouTube. [PDF]

Front Surg
Ozcan A, Gunes G.
europepmc   +1 more source

In Situ Programmable Modulation of Hydrogel Stiffness for Stage‐Adaptive Bone Regeneration

Advanced Science, EarlyView.
Near‐infrared (NIR) irradiation triggers Ca2+ release from thermoresponsive nanocarriers, enabling in situ stiffening of an adaptive hydrogel from a soft to a stiff state, thereby sequentially supporting mesenchymal stromal cell stemness and osteogenic differentiation for stage‐adaptive bone regeneration.
Yuxin Yang, Fan Yang, Lu Wang, Zongtai Li, Weichang Li, Xinchun Zhang   +5 more
wiley   +1 more source

Transanal irrigation for the management of low anterior resection syndrome (LARS): protocol for a pragmatic, multicentre, crossover randomised controlled trial. [PDF]

BMJ Open
Holland J, Demian M, Sabboobeh S, Oliveira CLP, Tang L, Bhatnagar S, Liberman AS, Drolet S, Brown C, Cahill C, Khorasani S, Zwiep T, Vasilevsky CA, Morin N, Pang A, Garfinkle R, Chadi SA, Abdulkarim S, Best G, Faria J, Ghitulescu G, Moloo H, Samuel L, Wexner S, Fiore JF, Boutros M.   +25 more
europepmc   +1 more source

EndoTac: An Endoscopic Camera‐Based Tactile Sensor with High Sensitivity for Minimally Invasive Surgery

Advanced Science, EarlyView.
EndoTac presents a trocar‐compatible endoscopic vision‐based tactile sensor that uses a convex mirror to enlarge side‐facing tactile coverage during minimally invasive vessel palpation. Distorted tactile images are unwarped and processed by a learning model to estimate vascular deformation, enabling sensitive, spatially distributed tactile perception ...
Yupeng Wang, Nicolas Raison, Xuyang Zhang, Aijia Yang, Lukas Lindenroth, Shan Luo   +5 more
wiley   +1 more source

The experiences of a structured pelvic floor rehabilitation program in colorectal cancer survivors with low anterior resection syndrome: A qualitative study. [PDF]

Support Care Cancer
Chan KYC, Ratcliffe SE, Collett G, Warusavitarne J, Suen M, Coulson S, Vardy JL.   +6 more
europepmc   +1 more source

Lanthanum Carbonate Nanosheets Based Colloidal Hydrogel for Modulating Innate & Adaptive Tumor Immunotherapy by Augmented Cellular Pyroptosis

Advanced Science, EarlyView.
The Gela/decitabine/La2(CO3)3 colloidal (GDLC) hydrogel developed here could reverse the epigenetic silencing of the GSDME gene by the synergistic interaction between DAC and La3+, while concurrently activating caspase‐3, thus facilitating pyroptosis induction under the tumor microenvironment.
Yang Hong, Haitao Wu, Weitao Wang, Xuan Zhang, Qian Chen, Yaoyu Hu, Zhengbao Zha   +6 more
wiley   +1 more source

Sacral neuromodulation improves bowel function in patients with low anterior resection syndrome. [PDF]

Tech Coloproctol
Issa A, Lutrin D, Yarchi S, Skvortsov R, Isa R, Weksler Y, Segev L, Horesh N, Ram E, Nachmany I, Carter D.   +10 more
europepmc   +1 more source