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Ondansetron for Low Anterior Resection Syndrome (LARS)

Annals of Surgery, 2023
Objective: The aim of the study was to examine the efficacity and safety of ondansetron, a serotonin receptor antagonist, to treat patients with low anterior resection syndrome (LARS). Background: LARS after rectal resection is common and debilitating.
Sotirios Georgios, Popeskou, Raffaello, Roesel, Seraina, Faes, Alice, Vanoni, Jacopo, Galafassi, Antonjacopo Ferrario, di Tor Vajana, Laure-Meline, Piotet, Dimitri, Christoforidis   +7 more
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Defining low anterior resection syndrome (LARS): Scoring tools and patient-reported outcomes

Seminars in Colon and Rectal Surgery, 2021
Abstract Low Anterior Resection Syndrome (LARS) groups together bowel dysfunction symptoms which occur after rectal resection, such as fecal incontinence, urgency, frequent bowel movements and clustering of stool. For adequate surgical outcome reporting, as well as to encompass all aspects of the condition, optimal syndrome definition and clinical ...
Jeremy Meyer
exaly   +2 more sources

Das Low anterior Resection Syndrome (LARS)

Zentralblatt Fur Chirurgie, 2019
Zusammenfassung Hintergrund Mit einem 5-Jahres-Überleben von mittlerweile 80% rückt die postoperative Lebensqualität nach onkologischer Rektumresektion zunehmend in den Fokus des Interesses. Das Low anterior Resection Syndrome (LARS) fasst die postoperative Morbidität infolge des operativen Eingriffes zusammen.
Udo Sulkowski, Rudolf Mennigen
exaly   +2 more sources

Incidence and Characterization of the Anterior Resection Syndrome Through the Use of the LARS Scale (Low Anterior Resection Score)

Cirugía Española (English Edition), 2016
Recently a score (LARS) has been internationally validates that quantifies the anterior resection syndrome (ARS). The objective of this study is to know the incidence and severity of the ARS using LARS and its correlation with selected variables or risk factors.All operated patients with anterior resection for rectal cancer between October 2007 and ...
Carlos Placer, Ander Timoteo, José M Enriquez-Navascues   +2 more
exaly   +3 more sources

Low anterior resection syndrome (LARS): cause and effect and reconstructive considerations

Techniques in Coloproctology, 2012
Between 25 and 80% of patients undergoing a low or very low anterior resection will suffer postoperatively, from a constellation of symptoms including fecal urgency, frequent bowel movements, bowel fragmentation and incontinence, collectively referred to as the low anterior resection syndrome (LARS).
Andrew Zbar, Y Ziv
exaly   +3 more sources

Outcome of bowel function following anterior resection for rectal cancer—an analysis using the low anterior resection syndrome (LARS) score

International Journal of Colorectal Disease, 2018
Severity of anorectal dysfunction after low anterior resection is associated with various patient- and treatment-related factors. We aimed to quantify anorectal dysfunction after treatment for rectal cancer using the low anterior resection syndrome (LARS) score.We retrieved from a prospective database 331 eligible patients on whom anterior resection ...
Sigmar Stelzner, Helmut Witzigmann
exaly   +3 more sources

A novel nomogram to predict low anterior resection syndrome (LARS) after ileostomy reversal for rectal cancer patients

European Journal of Surgical Oncology, 2023
Low anterior resection syndrome (LARS) in patients undergoing low or ultra-low anterior resection (LAR) is a common problem and significantly impacts the quality of life. Patients with an ileostomy after LAR are more likely to develop LARS. However, there hasn't been a model predicting LARS occurrence in these patients.
Feng Xia
exaly   +3 more sources

Systematic review of the management options available for low anterior resection syndrome (LARS)

Techniques in Coloproctology
Rectal cancer incidence is increasing. Low anterior resection is currently the gold standard surgical management. Postoperatively, patients may present with symptoms indicative of low anterior resection syndrome (LARS). LARS can be debilitating and is difficult to treat with low efficacy of treatment modalities. This systematic review aims to highlight
Gary Sharp, Nicholas Findlay
exaly   +5 more sources

Sacral neurostimulation for low anterior resection syndrome after radical resection for rectal cancer: evaluation of treatment with the LARS score

Techniques in Coloproctology, 2017
Sacral neurostimulation (SNS) has proven to be an effective treatment modality for low anterior resection syndrome (LARS). The primary aim of this study is to investigate the impact of SNS on all symptoms of LARS, not merely on fecal incontinence.
Mathieu D'Hondt, M D’Hondt
exaly   +3 more sources

Low anterior resection syndrome (LARS) in patients with epithelial ovarian cancer after primary debulking surgery

Gynecologic Oncology, 2019
To evaluate the prevalence of low anterior resection syndrome (LARS) in patients with debulking surgery for primary advanced epithelial ovarian cancer and to identify potential risk factors for development of LARS.We reviewed data on 552 consecutive patients with primary epithelial ovarian cancer (EOC), who underwent upfront or interval cytoreductive ...
Felix Harpain, Florian Heitz, Beyhan Ataseven   +2 more
exaly   +3 more sources