Results 61 to 70 of about 23,670 (281)

Deciphering and Targeting the Schwannoma‐Neuron‐Macrophage Crosstalk for the Treatment of Schwannomatosis and Associated Pain

Advanced Science, EarlyView.
We established patient‐derived SWN cell lines and orthotopic PDX models that recapitulate patient pain phenotypes, alongside a novel intravital DRG imaging platform to track macrophage infiltration and neuronal pain responses. Using these models, we define HMGB1–CCL2–IL‐6 signaling crosstalk driving pain and identify EGF signaling as a key regulator of
Zhenzhen Yin, Limeng Wu, Yanling Zhang, Yao Sun, Grace Y. Lee, Simeng Lu, Xing Gao, John W. Chen, Sonu Subudhi, William Ho, Chao Zhu, Jun Ren, Gino B. Ferraro, Alona Muzikansky, Anat Stemmer‐Rachamimov, Jianren Mao, Scott R. Plotkin, Lei Xu   +17 more
wiley   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

Low Anterior Resection Syndrome: Pathophysiology, Risk Factors, and Current Management

The Ewha Medical Journal, 2022
Low anterior resection syndrome (LARS) is a condition of anorectal dysfunction that occurs frequently following anal sphincter-preserving surgery for rectal cancer and can reduce the quality of life. In this review,
Seung Mi Yeo, Gyung Mo Son
doaj   +1 more source

Working Memory Deficits After Lesions Involving the Supplementary Motor Area. [PDF]

, 2018
Published: 23 May 2018The Supplementary Motor Area (SMA)—located in the superior and medial aspects of the superior frontal gyrus—is a preferential site of certain brain tumors and arteriovenous malformations, which often provoke the so-called SMA ...
Cañas, Alba, Gabarrós, Andreu, Hernández, Mireia, Juncadella, Montserrat, Lau, Ruth   +4 more
core   +3 more sources

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

Protocol for a single-arm confirmatory trial of adjuvant chemoradiation for patients with high-risk rectal submucosal invasive cancer after local resection: Japan Clinical Oncology Group Study JCOG1612 (RESCUE study)

BMJ Open, 2020
Introduction Intestinal resection with lymph node dissection is the current standard treatment for high-risk lower rectal submucosal invasive cancer after local resection; however, surgery affects patients’ quality of life due to stoma placement or ...
Kohei Shitara, Yutaka Saito, Ryoji Kushima, Manabu Muto, Masaaki Ito, Tomohiro Kadota, Hiroaki Ikematsu, Takeshi Sasaki, Tomonori Mizutani, Gakuto Ogawa, Yoshinori Ito, Yukihide Kanemitsu   +11 more
doaj   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Is transanal irrigation the best treatment possibility for low anterior resection syndrome? A multicenter, randomized clinical trial: study protocol

Frontiers in Surgery
BackgroundUp to 50% of patients who undergo rectal resection suffer from various and partly severe functional problems, despite the preservation of the anal sphincter. These complaints are defined as low anterior resection syndrome (LARS).
Michail Klimovskij, Ignas Civilka, Andrej Aleinikov, Tomas Aukstikalnis, Tomas Aukstikalnis, Peter Christensen, Peter Christensen, Audrius Dulskas, Audrius Dulskas   +8 more
doaj   +1 more source

Prevalence of low anterior resection syndrome and impact on quality of life after rectal cancer surgery: population‐based study

BJS Open, 2020
Background The prevalence of major low anterior resection syndrome (LARS) after rectal cancer surgery varies from 17·8 to 56·0 per cent, but data from high‐quality studies are sparse.
E. H. A. Pieniowski, C. Nordenvall, G. Palmer, A. Johar, S. Tumlin Ekelund, P. Lagergren, M. Abraham‐Nordling   +6 more
doaj   +1 more source

Visual Naming Performance after ATL Resection: Impact of Atypical Language Dominance. [PDF]

, 2010
Purpose- To characterize the interaction between language dominance and lateralization of the epileptic focus for pre- and postoperative Boston Naming Test (BNT) performance in patients undergoing anterior temporal lobectomy (ATL).
Alexopoulosa, A. V., Busch, R. M., Koubeissi, M. Z., Kovac, S., Lineweaver, Tara T., Loddenkemper, T., Möddel, G., Reinholz, J., Schuele, S. U., Syed, T.   +9 more
core   +2 more sources