Results 41 to 50 of about 414,779 (312)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Pattern and Determinants of Birth Weight in a Rural Popula-tion of Punjab, India

National Journal of Community Medicine, 2017
Introduction: Birth weight is a strong predictor for ensuring healthy life of a newborn and is affected by various maternal and social determinants.
Mahesh Satija, Vikram Kumar Gupta, Anurag Chaudhary, Sarit Sharma, Sangeeta Girdhar, Surinderpal Singh   +5 more
doaj  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Changing trends of birth weight with maternal age: a cross-sectional study in Xi’an city of Northwestern China

BMC Pregnancy and Childbirth, 2020
Background Most studies have shown that maternal age is associated with birth weight. However, the specific relationship between each additional year of maternal age and birth weight remains unclear.
Shanshan Wang, Liren Yang, Li Shang, Wenfang Yang, Cuifang Qi, Liyan Huang, Guilan Xie, Ruiqi Wang, Mei Chun Chung   +8 more
doaj   +1 more source

Effect of Zinc Supplementation on Growth of Low Birth Weight Infants Aged 1–6 Mo in Ardabil, Iran [PDF]

Objective To assess the effect of zinc supplementation on growth of low birth weight (LBW) infants aged 1–6 mo. Methods LBW infants were enrolled at birth and randomly assigned to receive 5 mg elemental Zn per day (n=45) or placebo (n=45) until 6 mo of ...
امینی ثانی, نیره, شمشیرگران, سید مرتضی, Seyed Morteza Shamshirgaran, Manuchehr Barak, براک, منوچهر, Nayyereh Aminisani   +5 more
core   +1 more source

Low birth weight and its association factors in Iran: according world health organization model

Journal of Rehabilitation, 2012
Objective: Birth weight is one of the most important ,simplest and common determinations for assessments infants status in each country. this study has been designed to investigate the articles that published in its prevalence and related factors ...
zohreh Mahmoudi, Masoud Karimlou, Homeira Sajjadi, Ma'soumeh Dejman, Marveh Vameghi   +4 more
doaj  

Genetic variation in the 15q25 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) interacts with maternal self-reported smoking status during pregnancy to influence birth weight [PDF]

, 2012
Maternal smoking during pregnancy is associated with low birth weight. Common variation at rs1051730 is robustly associated with smoking quantity and was recently shown to influence smoking cessation during pregnancy, but its influence on birth weight is
Paternoster, Lavinia, Freathy, R.M., Ng, J.W.Y., Johnson, P.C.D., Watt, GCM, Ebrahim, S, Potter, C, Hartikainen, A.L., Lowe, William L., Potter, C. (Catherine), Johnson, PC, Watt, GC, Ng, JWY, Ebrahim, Shah, Taal, H.R., Christie, J.D. (Jason), Lowe Jr., W.L. (William), Johnson, P., Hattersley, Andrew T., Watt, G.C.M., Brion, M.-J.A., Kaakinen, M, Brion, M.-J. (Maria), Sorensen, T.I.A., Geller, F. (Frank), Sørensen, Thorkild IA, Ng, Jane WY, Cavadino, Alana, Kaakinen, Marika, Freathy, RM, Myhre, R. (Ronny), Johnson, Paul CD, Freathy, R.M. (Rachel), Lowe, LP, Hofman, Bert, Johnson, Paul C D, Brion, MJ, Sengpiel, V. (Verena), Hypponen, Elina, Davey Smith, George, Cavadino, A, Huikari, V, Ebrahim, S., Hartikainen, A., Frayling, Timothy M., Taal, HR, Sebert, SP, Lawlor, D.A. (Debbie), Murray, J.C., Huikari, V. (Ville), Lowe, L., Hofman, A., Brion, M., Sattar, Naveed, Jaddoe, Vincent W. V., Hartikainen, Anna-Liisa, Johnson, P.C.D. (Paul C.), Jarvelin, Marjo-Riitta, Hartikainen, AL, Bakker, R, Nohr, EA, Murray, J.C. (Jeffrey), Paternoster, L., Sattar, N, Lowe, L.P. (Lynn), Pennell, C.E., Smith, GD, Smith, G. D., Jacobsson, Bo, Power, C., Hattersley, A.T., Magnus, P, Sengpiel, Verena,, Magnus, Per,, Sorensen, Thorkild, Jarvelin, M.-R. (Marjo-Riitta), ?, ?, Lawlor, DA, Melbye, M. (Mads), Relton, C.L., et al., Lawlor, D.A., Pennell, Craig E., Jacobsson, B., Christie, Jennifer T, Myhre, R, Power, Chris, Ring, Susan M, McConnachie, A. (Alex), Davey Smith, G, Melbye, Mads, Pennell, C.E. (Craig), Relton, Caroline L., Jaddoe, Vincent W V, Sørensen, TIA, Lawlor, Debbie A., Freathy, Rachel M., Frayling, Timothy M, Watt, Graham C M, Jaddoe, VW, Srensen, TIA, Jaddoe, VWV, Jacobsson, B. (Bo), Cavadino, A., Pennell, CE, Jacobsson, Bo,, Cavadino, A. (Alana), Tyrrell, Jessica S., Pennell, Craig E, Hartikainen, A.-L., Relton, Caroline L, Early Growth Genetics (EGG) Consortium, Lowe, WL, Ring, SM, Lowe, Lynn P., Feenstra, B, Sattar, N. (Naveed), Potter, C., Feenstra, B., McConnachie, A, Hattersley, Andrew T, Hattersley, A.T. (Andrew), Sengpiel, V., Smith, George Davey, Nohr, E.A., Feenstra, B. (Bjarke), Ng, J.W. (Jane), Watt, G.C. (Graham), Srensen, Thorkild IA, Ring, S.M., Freathy, Rachel M, Sengpiel, V, Hofman, A. (Albert), Hattersley, AT, Sebert, S.P., Kaakinen, M., Geller, F, Nohr, C. (Christian), Sattar, N., Sengpiel, Verena, Jaddoe, Vincent WV, Huikari, Ville, Power, C, Tyrrell, Jessica, Lawlor, Debbie A, Feenstra, Bjarke, Lowe, Lynn P, Jacobsson, B, Taal, Rob; id_orcid, Sørensen, T.I.A. (Thorkild), Paternoster, L. (Lavinia), Jaddoe, V.W.V. (Vincent), Brion, Marie-Jo A, Frayling, T.M. (Timothy), Hypponen, E. (Elina), Hattersley, A., Brion, MJA, Relton, CL, Christie, Jennifer T., Sebert, Sylvain P., Jaddoe, Vincent, Johnson, PCD, Frayling, TM, Christie, JT, Murray, JC, Johnson, Paul C. D., Tyrrell, A.W.R., Jaddoe, V.W.V., Jarvelin, MR, Magnus, P. (Per), Myhre, Ronny, Power, C. (Christopher), Sørensen, TI, Lowe, William L, Geller, Frank, Murray, Jeffrey C., Bakker, R., Jarvelin, M.-R., Hypponen, E., Taal, H Rob, Relton, C.L. (Caroline), McConnachie, A., Nohr, Ellen A, Christie, J., Murray, Jeffrey C, Nohr, Ellen A., McConnachie, Alex, Christie, J.T., Hofman, A, Bakker, R. (Rachel), Frayling, T.M., Watt, Graham C. M., Hypponen, E, Melbye, M, Ng, JW, Smith, A.V. (Davey), Taal, H. Rob, Hofman, Albert, Ring, S.M. (Susan), Huikari, V., Ring, Susan M., Sebert, Sylvain P, Tyrrell, J, Taal, H.R. (Rob), Magnus, P., Lowe, L.P., Lowe, W. L., Ng, Jane W. Y., Tyrrell, J., Ebrahim, S. (Shanil), Sørensen, Thorkild I A, Myhre, R., Magnus, Per, Sebert, S. (Sylvain), Kaakinen, M. (Marika), Bakker, Rachel, Ng, Jane W Y, Taal, Rob, Geller, F., Potter, Catherine, Paternoster, L, Melbye, M., Watt, Graham CM, Brion, Marie-Jo A.   +223 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source