Results 41 to 50 of about 11,372,038 (312)

Type 2 Diabetes Risk Alleles Are Associated With Reduced Size at Birth [PDF]

, 2009
OBJECTIVE: Low birth weight is associated with an increased risk of type 2 diabetes. The mechanisms underlying this association are unknown and may represent intrauterine programming or two phenotypes of one genotype.
Timpson, NJ, Ruokonen, A, Weedon, Michael N, Hattersley, AT, McCarthy, MI, Pouta, Anneli, Lindgren, Cecilia M, Perry, JR, Weedon, MN, Elliott, P, Groves, Christopher J, Smith, GD, Shields, B, Power, C, Järvelin, MR, Hyppönen, E, Shields, Beverley, Zeggini, Eleftheria, McCarthy, Mark I, Bennett, Amanda J, Ring, Susan M, Power, Chris, Ring, SM, Ruokonen, Aimo, Pouta, A, Strachan, DP, Elliott, Paul, Järvelin, Marjo-Riitta, Timpson, Nicholas J, Lango, Hana, Groves, CJ, Bennett, AJ, Hattersley, Andrew T, Lindgren, CM, Smith, George Davey, Zeggini, E, Frayling, Timothy M, Strachan, David P, Lango, H, Hyppönen, Elina, Freathy, RM, Perry, John R B, Frayling, TM, Freathy, Rachel M, Freathy, R.M., Hypponen, E., Hattersley, A.T., Shields, B., Ring, S.M., Bennett, A.J.   +49 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Pattern and Determinants of Birth Weight in a Rural Popula-tion of Punjab, India

National Journal of Community Medicine, 2017
Introduction: Birth weight is a strong predictor for ensuring healthy life of a newborn and is affected by various maternal and social determinants.
Mahesh Satija, Vikram Kumar Gupta, Anurag Chaudhary, Sarit Sharma, Sangeeta Girdhar, Surinderpal Singh   +5 more
doaj  

Factors associated with weight Z-score in very low birth weight and extremely low birth weight preterm infants during hospitalization

Jornal de Pediatria
Objective: To investigate the behavior of weight-for-age z-score (WAZ) and associated factors in preterm newborns (PTNB) with very low birth weight (VLBW) and extremely low birth weight (ELBW), comparing them to low birth weight (LBW) during four weeks ...
Eduarda Couto Plácido Nunes, Eduarda Silva, Eduarda Dallmann Lopes Pereira, Karla Pereira Machado, Sandra Costa Valle   +4 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Birth weight and cognitive function in the British 1946 birth cohort: longitudinal population based study [PDF]

, 2001
Objective To examine the association between birth weight and cognitive function in the normal population.Design A longitudinal, population based, birth cohort study.Participants 3900 males and females born in 1946.Main outcome measures Cognitive ...
Richards, M, Hardy, R, Wadsworth, MEJ, Kuh, D   +3 more
core  

Low birth weight and its association factors in Iran: according world health organization model

Journal of Rehabilitation, 2012
Objective: Birth weight is one of the most important ,simplest and common determinations for assessments infants status in each country. this study has been designed to investigate the articles that published in its prevalence and related factors ...
zohreh Mahmoudi, Masoud Karimlou, Homeira Sajjadi, Ma'soumeh Dejman, Marveh Vameghi   +4 more
doaj  

Low birth weight in the United States [PDF]

The American Journal of Clinical Nutrition, 2007
Pregnancy outcomes in the United States and other developed countries are considerably better than those in many developing countries. However, adverse pregnancy outcomes are generally more common in the United States than in other developed countries. Low-birth-weight infants, born after a preterm birth or secondary to intrauterine growth restriction,
Robert L, Goldenberg, Jennifer F, Culhane   +1 more
openaire   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Effect of Zinc Supplementation on Growth of Low Birth Weight Infants Aged 1–6 Mo in Ardabil, Iran [PDF]

Objective To assess the effect of zinc supplementation on growth of low birth weight (LBW) infants aged 1–6 mo. Methods LBW infants were enrolled at birth and randomly assigned to receive 5 mg elemental Zn per day (n=45) or placebo (n=45) until 6 mo of ...
امینی ثانی, نیره, شمشیرگران, سید مرتضی, Seyed Morteza Shamshirgaran, Manuchehr Barak, براک, منوچهر, Nayyereh Aminisani   +5 more
core   +1 more source