Results 111 to 120 of about 1,082,608 (346)

Serum insulin-like growth factor binding protein-2 levels as an indicator of functional ability in elderly men [PDF]

, 2003
BACKGROUND: In a cross-sectional study in 403 healthy, independently living elderly men (mean age 78 years), we determined which are the main physiological determinants of functional ability in the elderly, and which components of the ...
Beld, A.W. (Annewieke) van den, Blum, W.F. (Werner), Grobbee, D.E. (Diederick), Lamberts, S.W.J. (Steven), Pols, H.A.P. (Huib)   +4 more
core   +1 more source

Effect of Foot Orthoses on Midfoot Pain and the Volume of Bone Marrow Lesions in the Midfoot: A Randomized Mechanism of Action Study

Arthritis Care &Research, EarlyView.
Objective Foot orthoses are thought to improve pain by potentially modifying internal mechanical forces. To test this, we explored whether foot orthoses can modify patterns of bone marrow lesions (BMLs) in people with midfoot pain. Methods Forty‐two people were recruited with midfoot pain, and magnetic resonance imaging–confirmed midfoot BMLs ...
Jill Halstead, Anne‐Maree Keenan, Philip G. Conaghan, Dennis McGonagle, Anthony C. Redmond   +4 more
wiley   +1 more source

Lef1 haploinsufficient mice display a low turnover and low bone mass phenotype in a gender- and age-specific manner.

PLoS ONE, 2009
We investigated the role of Lef1, one of the four transcription factors that transmit Wnt signaling to the genome, in the regulation of bone mass. Microcomputed tomographic analysis of 13- and 17-week-old mice revealed significantly reduced trabecular ...
Tommy Noh, Yankel Gabet, Jon Cogan, Yunfan Shi, Archana Tank, Tomoyo Sasaki, Braden Criswell, Alexis Dixon, Christopher Lee, Joseph Tam, Thomas Kohler, Eran Segev, Lisa Kockeritz, James Woodgett, Ralph Müller, Yang Chai, Elisheva Smith, Itai Bab, Baruch Frenkel   +18 more
doaj   +1 more source

Osteoporosis in young adults: pathophysiology, diagnosis, and management [PDF]

, 2018
Postmenopausal osteoporosis is mainly caused by increased bone remodeling resulting from estrogen deficiency. Indications for treatment are based on low areal bone mineral density (aBMD, T-score ≤ −2.5), typical fragility fractures (spine or hip), and ...
Adami, S., Bianchi, M., de Vernejoul, M.-C, Eisman, J., Ferrari, S., Foldes, A., Kaufman, J.-M, Stepan, J., Wahl, D.   +8 more
core  

Modifications in Bone Matrix of Estrogen-Deficient Rats Treated with Intermittent PTH [PDF]

, 2015
Bone matrix dictates strength, elasticity, and stiffness to the bone. Intermittent parathyroid hormone (iPTH), a bone-forming treatment, is widely used as a therapy for osteoporosis.
Campos, Jenifer Freitas, de Medeiros, Valquíria Pereira, Katchburian, Eduardo, Nader, Helena Bonciani, Nonaka, Keico Okino, Pacheco-Costa, Rafael, Plotkin, Lilian Irene, Reginato, Rejane Daniele   +7 more
core   +3 more sources

A Qualitative Analysis of Patient Perspectives and Preferences in Lupus Management to Guide Lupus Guidelines Development

Arthritis Care &Research, EarlyView.
Objective A patient‐centered approach for chronic disease management, including systemic lupus erythematosus (SLE), aligns treatment with patients’ values and preferences, leading to improved outcomes. This paper summarizes how patient experiences, perspectives, and priorities informed the American College of Rheumatology (ACR) 2024 Lupus Nephritis (LN)
Shivani Garg, Izzy Hartel, Lisa R. Sammaritano, Anca Askanase, Bonnie L. Bermas, Maria Dall'Era, Alí Duarte‐García, Victoria P. Werth, Brad Rovin, Reem A. Mustafa, Amy S. Turner, Bené Williams, Brian L. Ung, Hiya Bhavsar, Monique C. Gore‐Massy, Nahirannette Pulido, Natacha Guerrero, Natalie M. Smith, Wambui Machua, Linda T. Hiraki, Mary Beth Son   +20 more
wiley   +1 more source

Role of Prednisone and 25‐Hydroxyvitamin D on Bone Mineral Density and Osteoporosis in Systemic Lupus Erythematosus

Arthritis Care &Research, EarlyView.
Objective We evaluated the role of 25‐hydroxyvitamin D (25[OH]D), prednisone, and other risk factors for bone mineral density (BMD) loss and osteoporosis in systemic lupus erythematosus (SLE). Methods We calculated the association between 25(OH)D levels and other potential risk factors and BMD measures (spine T scores) and osteoporosis (defined as a T ...
Nima Madanchi, Andrea Fava, Daniel W. Goldman, Laurence S. Magder, Michelle Petri   +4 more
wiley   +1 more source

The frequency of osteogenic activities and the pattern of intermittence between periods of physical activity and sedentary behaviour affects bone mineral content: the cross-sectional NHANES study [PDF]

, 2014
BACKGROUND: Sedentary behaviours, defined as non exercising seated activities, have been shown to have deleterious effects on health. It has been hypothesised that too much sitting time can have a detrimental effect on bone health in youth.
A Bauman, A Caillot-Augusseau, A-L Barabási, AG Robling, AS Goktepe, AYY Ho, B Fan, C Cooper, C Mattocks, CA Bailey, CA Celis-Morales, CE Matthews, CE Matthews, CF Kunkel, CJ Hernandez, Dawn A Skelton, DC Welten, DE Garland, Department of Health, DW Marquardt, ER Morey-Holton, F Rauch, G Vicente-Rodríguez, G Vicente-Rodríguez, H Kim, J Salmon, JA Kanis, JE Zerwekh, JM Caulton, JP Callaghan, KI Eleftheriou, KR Evenson, L Gracia-Marco, L Gracia-Marco, M Ben, MR Forwood, MS Tremblay, N Owen, network S behavior research, Oleksii Mandrichenko, OO Babatunde, P Pitukcheewanont, PS Freedson, RP Heaney, S Baim, S Chastin, Sebastien FM Chastin, SFM Chastin, SL Hui, T Kato, WH Dietz, Y Umemura   +51 more
core   +2 more sources

The temporal trends and short‐ and long‐term mortality of people with acute myocardial infarction and rheumatoid arthritis: a nationwide cohort study

Arthritis Care &Research, Accepted Article.
Aims We investigated whether a diagnosis of rheumatoid arthritis (RA) affects the quality of inpatient acute myocardial infarction (AMI) care and long‐term mortality post‐AMI. Methods We analysed data from 784,091 adults, 6,047 with a diagnosis of RA, from England and Wales hospitalised with AMI between 2005 and 2019 from the MINAP registry, linked ...
Megan Butler, Nicholas Weight, Muhammad Rashid, Rodrigo Bagur, Purvi Parwani, Samantha Hider, Edward Roddy, Robert Butler, Mamas A Mamas   +8 more
wiley   +1 more source

Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiation [PDF]

, 2017
The NLRP3 inflammasome senses a variety of signals referred to as danger associated molecular patterns (DAMPs), including those triggered by crystalline particulates or degradation products of extracellular matrix. Since some DAMPs confer tissue-specific
Abu-Amer, Yousef, Alippe, Yael, Civitelli, Roberto, Mbalaviele, Gabriel, Novack, Deborah V, Qu, Chao, Ricci, Biancamaria, Wang, Chun, Xiao, Jianqiu, Zou, Wei   +9 more
core   +2 more sources