Advanced Science, EarlyView.Through integrated proteomic and metabolomic profiling, Zhao et al. identified three molecular subtypes of high‐grade serous ovarian cancer. The high‐risk subtype exhibits activated arachidonic acid metabolism and cyclooxygenase‐2 overexpression. This metabolic axis promotes M2‐like macrophage infiltration, which contributes to platinum resistance ...
Yuxi Zhao +11 more
wiley +1 more source
Low-Carbohydrate Diet and Metabolic Syndrome Risk in Korean Adults: A Korea National Health and Nutrition Examination Survey Study. [PDF]
NutrientsRajaguru V +5 more
europepmc +1 more source
Advanced Science, EarlyView.Aberrant GALNT7‐mediated O‐GalNAcylation stabilizes TAZ to drive gallbladder cancer progression through a feed‐forward transcriptional loop. Structure‐based screening identifies Olaparib as a potent GALNT7 antagonist that disrupts this oncogenic axis, providing an immediate therapeutic strategy for this aggressive malignancy.
Peng Qiu +11 more
wiley +1 more source
Hedonic hunger and eating behavior after low-carbohydrate versus low-fat diets in females with lipedema and obesity. [PDF]
Front NutrLundanes J +4 more
europepmc +1 more source
Advanced Science, EarlyView.An artificial bifunctional N‐deacetylase/N‐sulfotransferase was engineered in Escherichia coli by combining screened N‐deacetylases with an NST domain. The integrated engineering strategy improved enzyme performance. The optimized enzyme efficiently converted heparosan into N‐sulfated heparosan, addressing a key bottleneck in microbial heparin ...
Xintong Xi +8 more
wiley +1 more source
Impact of a remote nutrition education on low-carbohydrate diet based in type 2 diabetes management: findings from a Brazilian primary care randomized controlled trial. [PDF]
Diabetol IntBalbinot GS, Costódio RS, Vicentini GE.
europepmc +1 more source
Controlled Peptide Capture and Release in 3D‐Printed Multimaterial Microstructures
Advanced Science, EarlyView.Two‐photon laser printing of 3D microstructures using a peptide‐containing ink is shown. The microstructures allow for controlled capture and release of target peptides through coiled‐coil interaction with the printed peptide inside the material. Based on these properties, orthogonal capture and stimuli‐mediated release possibilities inside printed ...
Niklas Schwegler +4 more
wiley +1 more source
Critical methodological concerns regarding the secondary analysis of a low-carbohydrate diet trial on frailty in older diabetic patients. [PDF]
J Diabetes InvestigZhou L, Fu Y.
europepmc +1 more source
Advanced Science, EarlyView.Cross‐disciplinary endeavors are blossoming across the broad chemical sciences. This perspective provides a glimpse into the rewarding interdisciplinary journey taken by the Charles Loh research group in pioneering the σ‐hole based catalytic glycosylation strategy.
Charles C. J. Loh
wiley +1 more source
Association of low-carbohydrate-diet score and osteoporotic fractures: National Health and Nutrition Examination Survey. [PDF]
Front Public HealthShen Y, Wei H.
europepmc +1 more source