Results 111 to 120 of about 10,534,234 (296)

Equation Calculator for Low-Density Lipoprotein Cholesterol

, 2020
A new low-density lipoprotein cholesterol equation was derived with results from a standard lipid panel that can be used to more accurately estimate the low-density lipoprotein cholesterol level in patients with plasma triglyceride levels up to 800 mg/dL
Alan T. Remaley (8495765), James Fleming (8495728), Marcelo Amar (8495762), Roa Harb (8495694), Robert Shamburek (8495759), Clarence Ling (8495681), Jeff Meeusen (8495732), Maureen Sampson (8495625), Allan Jaffe (8495755), Qian Sun (8495689), Mohmed Ashmaig (8495705), Sarah Delaney (8495745), Amar Sethi (8495725), James Otvos (8495729), Russell Warnick (8495710)   +14 more
core   +1 more source

Copper‐Doped Prussian Blue Nanozymes With Hyaluronic Acid‐Mediated Targeting Alleviate Oxidative Stress and Regulate Cholesterol Handling for Atherosclerosis Therapy

Advanced Science, EarlyView.
CuPB@HA is a CD44‐associated, plaque‐targeted nanozyme that alleviates oxidative stress, inflammation, and lipid accumulation in macrophages. By reducing CD36‐dependent lipid uptake and promoting ABCA1/ABCG1‐mediated cholesterol handling, it improves macrophage function, preferentially accumulates in atherosclerotic lesions, reduces plaque burden, and ...
Jianliang Ou, Ruihua Ji, Qinglu Zang, Mingkang Wang, Lingling Zhou, Yingliang Wei, Di Yang, Yue Wu, Hongxu Zhu, Jianrong Wu, Xiaojun Cai, Wenxian Du, Junjie Cheng, An Zeng, Yuehua Li   +14 more
wiley   +1 more source

Relationship between low-density lipoprotein cholesterol and severe acute pancreatitis (“the lipid paradox”)

, 2018
Wandong Hong,1,* Vincent Zimmer,2,3,* Simon Stock,4,* Maddalena Zippi,5 Jones AQ Omoshoro-Jones,6 Mengtao Zhou71Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People’s ...
Zhou M, Zimmer V, Hong W, Stock S, Zippi M, Omoshoro-Jones JAQ   +5 more
core  

Plaque‐Hepatic Targeting Nanotherapy Disrupts the PCSK9‐LOX‐1 Axis to Suppress oxLDL in Atherosclerosis

Advanced Science, EarlyView.
Self‑amplifying PCSK9–LOX‑1 feedback axis drives atherosclerotic progression by promoting oxLDL generation and endothelial uptake. A dual‑targeting nanoplatform (siPCSK9@PEAL NPs‑aL) is constructed to simultaneously silence hepatic PCSK9 for lipid lowering and block plaque LOX‑1 for anti‑inflammation.
Yi Duan, Yijie Qiu, Yan Zhu, Quan Wang, Jiangtao Lin, Yourong Duan, Qi Wang, Yi Dong   +7 more
wiley   +1 more source

Metabolic Memory in Cardiovascular Disease: Encoding, Propagation, and Therapeutic Targeting

Advanced Science, EarlyView.
Cardiovascular risk often persists after metabolic abnormalities are corrected. This conceptual Review frames such persistence as metabolic memory, encoded through a narrowing therapeutic window from reversible marks to irreversible damage, with continuous input from peripheral organs.
Cheng Cheng, Minghui Tang, Zhaobo Zhang, Ruoyi Qu, Jianfei Pei, Tian Liu, Siyao Qu, Shilong You, Shenshen Cui, Wenke Wang, Rui Zhao, Yingxian Sun, Naijin Zhang   +12 more
wiley   +1 more source

Compact 9dBEs Enable Efficient and Precise Genome Editing in Mammalian Cells and In Vivo

Advanced Science, EarlyView.
As a compact type II‐D system, the Cas9d‐based platform holds great potential for in vivo applications. Through rational engineering, its derived base editors (9dBEs) enable efficient disease modeling while facilitating single‐vector AAV delivery for in vivo genome editing. These miniature tools offer a robust strategy for basic research and biomedical
Qingquan Xiao, Zhijin Tian, Luqi Weng, Kun Xu, Dingyi Han, Zhaowei Wu, Junnan Li, Shangpu Li, Qijing Zhang, Xiaohui Zhao, Guoling Li, Yinghui Wei, Zhen Gu   +12 more
wiley   +1 more source

The characterisation of the ectodomain shedding of the low density lipoprotein receptor [PDF]

, 2009
Includes abstract. Includes bibliographical references (leaves 142-155)
Parker, Ayesha
core   +1 more source

THSD7A Exacerbates Atherosclerosis via Activation of Signaling Axis αvβ3/CEBPD/IL1A

Advanced Science, EarlyView.
THSD7A exerts pro‐inflammatory effects and exacerbates atherosclerosis. Mechanistically, THSD7A regulates endothelial cell inflammation and atherosclerosis by activating the αvβ3/CEBPD/IL1A signaling axis. THSD7A is not only a genetic marker but also a potential therapeutic target for coronary artery disease (CAD).
Jiankun Liu, Hongfei Liu, Yiqi Wan, Andong Wu, Jiayu Qiu, Xueting Gong, Ya Zhao, Yuanyuan Li, Bingbing Zhou, Yangyi Zheng, Fang Wu, Yuanzheng Zhu, Weixin Lv, Xueer Li, Qiang Yuan, Xiao‐Li Tian   +15 more
wiley   +1 more source

Genetic Variation in FADS Genes and Plasma Cholesterol Levels in 2-Year-Old Infants [PDF]

, 2013
Single nucleotide polymorphisms (SNPs) in genes involved in fatty acid metabolism (FADS1 FADS2 gene cluster) are associated with plasma lipid levels. We aimed to investigate whether these associations are already present early in life and compare the ...
Moltó-Puigmartí Carolina, Penders, J., Ronald P Mensink, Carolina Moltó-Puigmartí (5261441), Jogchum Plat (302633), Thijs Carel, Monique Mommers, Thijs, Carel, Mommers, Monique, Eugène Jansen, Dirkje S Postma, Mensink Ronald P., John Penders (396322), Mommers Monique, Plat, J., Mensink, Ronald P., Koppelman, Gerard H., Standl Marie, Dirkje S. Postma (101740), Joachim Heinrich (60421), Postma, D.S., Jansen, Eugène, Standl, Marie, Moltó-Puigmartí, Carolina, Penders John, Koppelman Gerard H., Heinrich Joachim, Mensink, R.P., Thijs, C., Gerard H. Koppelman (153163), Postma, Dirkje S., Moltó-Puigmarti, C., Plat Jogchum, Carolina Moltó-Puigmartí, Carel Thijs (112720), Postma Dirkje S., Jansen, E., Joachim Heinrich, Marie Standl, Carel Thijs, Heinrich, Joachim, Jogchum Plat, Mommers, M., Standl, M., Monique Mommers (112709), Heinrich, J., Ronald P. Mensink (302629), Koppelman, Gerard H.; id_orcid, John Penders, Eugène Jansen (123572), Marie Standl (163136), Thijs, C.; id_orcid, Plat, Jogchum, Penders, John, Gerard H Koppelman, Koppelman, G.H., Jansen Eugène   +56 more
core   +3 more sources

OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD

Advanced Science, EarlyView.
This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li, Jingyue Song, Kaili Ma, Shunan Tang, Shuqian Wang, Wenya Ji, Chen Lu, Ting Zhang, Huaping Zheng, Xiaowei Zheng, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source