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Opportunistic Genomic Screening for Familial Hypercholesterolemia to Improve Low-Density Lipoprotein Cholesterol: A Randomized Clinical Trial.

JAMA Netw Open
Vassy JL, Brunette CA, Yi T, Assimes TL, Christensen KD, Knowles JW, Sturm AC, Sun YV, Alexander N, Cardellino MP, Harrison A, Gerety HL, Pyatt M, Vered R, Wilson PWF, Natarajan P, Whitbourne SB, Gaziano JM, Muralidhar S, Danowski ME, Veterans Affairs Million Veteran Program.   +20 more
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Evaluation of Malondialdehyde Low-Density Lipoprotein Stratified by Low-Density Lipoprotein Cholesterol

Clinical Laboratory, 2017
Malondialdehyde low-density lipoprotein (MDA-LDL) is a major form of oxidized LDL and considered to be more atherogenic than LDL. Information on major determinants of MDA-LDL and their association in subjects who are not under treatment for diabetes mellitus and dyslipidemia is limited.This study included 778 Japanese subjects who were not taking ...
Kengo, Moriyama, Eiko, Takahashi
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Cyclosporine, Low-Density Lipoprotein, and Cholesterol

Mayo Clinic Proceedings, 1988
Lipoproteins are known to be able to transport a variety of drugs. This report suggests that low-density lipoprotein not only functions as an important carrier of cyclosporine in plasma but also facilitates transport of cyclosporine across the cell membrane by means of the low-density lipoprotein receptor. Such a mechanism would explain (1) the similar
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Low-Density Lipoprotein Cholesterol in Subclinical Hypothyroidism

Thyroid, 2000
The significance of subclinical hypothyroidism in regard to ensuing hyperlipidemia remains unclear. Because an unfavorable lipid profile would provide a possible explanation for the reported association of coronary-heart disease with this syndrome, we have evaluated the relationship of thyrotropin (TSH) with total cholesterol, low-density-lipoprotein ...
H, Vierhapper, A, Nardi, P, Grösser, W, Raber, A, Gessl   +4 more
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Reaching low density lipoprotein cholesterol targets

Current Medical Research and Opinion, 2014
Cardiovascular disease is a major health problem and within the leading causes of death worldwide. Low-density lipoprotein cholesterol (LDL-C) is strongly associated with the development and progression of cardiovascular disease and is among the main targets of lipid lowering therapy.
Christos V, Rizos, Fotios, Barkas, Moses S, Elisaf   +2 more
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“Isolated” Low High-Density Lipoprotein Cholesterol

Annals of Pharmacotherapy, 1997
OBJECTIVE: To present information on the function, structure, and importance of high-density lipoprotein cholesterol (HDL-C) and to evaluate the current literature regarding the controversy of managing patients with an “isolated” low HDL-C concentration ...
V M, Wilt, J G, Gums
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Reliability of Calculated Low-Density Lipoprotein Cholesterol

The American Journal of Cardiology, 2015
Aggressive low-density lipoprotein cholesterol (LDL-C)-lowering strategies are recommended for prevention of cardiovascular events in high-risk populations. Guidelines recommend a 30% to 50% reduction in at-risk patients even when LDL-C concentrations are between 70 and 130 mg/dl (1.8 to 3.4 mmol/L).
Jeffrey W, Meeusen, Christine L, Snozek, Nikola A, Baumann, Allan S, Jaffe, Amy K, Saenger   +4 more
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Direct testing for low-density lipoprotein cholesterol

The American Journal of Cardiology, 1995
6. Ismen S. Olsen K, Jacohscn E. IGclscn H, S&en A. Pietensen A. Jensen 0. Pedenen I-‘, Waahcn J. Kehlet H. Hansen J. Dalgaard P. Nyboe J. Predictmu of cardiac risk in non-cardiac surgery. Lur f&w? J I9R7:8:179 18.5. 7. Ashmn C, Pewson Ii. Wray N, Kiefe C. Dunn J. Wu 1.. Thomas J.
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Update on low-density lipoprotein cholesterol quantification

Current Opinion in Lipidology, 2019
Purpose of review β-Quantification is considered the reference measurement procedure for low-density lipoprotein cholesterol (LDL-C). However, this technique is time-consuming and thus is inappropriate for routine clinical practice. Therefore, the Friedewald equation or homogeneous assays have been widely utilized.
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