Results 81 to 90 of about 10,534,234 (296)

Low‐Density Lipoprotein Cholesterol and Mortality in Older People [PDF]

Journal of the American Geriatrics Society, 2005
Objectives: To investigate the role of low‐density lipoprotein cholesterol (LDL‐C) as a predictor of mortality in elderly subjects. Design: Population‐based prospective cohort study.
TIKHONOFF, VALERIE, CASIGLIA, EDOARDO, MAZZA, ALBERTO, SCARPA R., TIJS L., PESSINA, ACHILLE CESARE, STAESSEN J. A.   +6 more
openaire   +3 more sources

Association of the Low-density Lipoprotein Cholesterol/High-density Lipoprotein Cholesterol Ratio with Glecaprevir-pibrentasvir Treatment

Internal Medicine, 2021
Objective The change in serum lipid levels by direct-acting antiviral (DAA) treatment for chronic hepatitis C varies depending on the type of DAA. How the lipid level changes induced by glecaprevir-pibrentasvir (G/P) treatment contribute to the clinical outcome remains unclear.
Akutsu, Noriyuki, Sasaki, Shigeru, Matsui, Takeshi, Akashi, Hirofumi, Yonezawa, Kazuhiko, Ishigami, Keisuke, Tsujisaki, Masayuki, Isshiki, Hiroyuki, Yawata, Atsushi, Yamaoka, Satoshi, Ban, Toshihiro, Adachi, Takeya, Nakahara, Seiya, Takagi, Hideyasu, Nakachi, Kohei, Tanaka, Katsunori, Hirano, Takehiro, Yamamoto, Itaru, Kaneto, Hiroyuki, Wagatsuma, Kohei, Numata, Yasunao, Nakase, Hiroshi   +21 more
openaire   +3 more sources

How is Nanoarchitectonics Shaping Extracellular Vesicle Research?

Advanced Healthcare Materials, EarlyView.
The convergence of nanoarchitectonics and extracellular vesicle biology is reshaping next‐generation nanomedicine by enabling rationally designed nanostructures for enhanced EVs detection, engineering, and therapy. ABSTRACT Extracellular vesicles (EVs) have gained recognition as crucial mediators of cell‐to‐cell communication, holding immense potential
Madushani Dahanayake, Md Shahriar A. Hossain, Chia‐Hung Liu, Carlos Salomon, Yusuke Yamauchi, Mostafa Kamal Masud   +5 more
wiley   +1 more source

Urinary cholesterol: its association with a macromolecular protein- lipid complex [PDF]

, 1984
The cholesterol-containing complexes in the urine of normal subjects and patients with diseases accompanied by hyperexcretion of urinary cholesterol were characterized. In normal subjects, the major portion of the recovered urinary cholesterol was eluted
Jüngst, Dieter, Siess, E., Weiser, H., Karl, Hans Josef   +3 more
core   +1 more source

Baseline and follow-up change of cholesterol levels predict dementia risk and progression in older adults: a U-shaped relationship

Alzheimer’s Research & Therapy
Introduction Previous studies on serum lipid levels and cognitive outcomes have shown inconsistent results, partly due to differences in timing of lipid assessment, cognitive status, and lack of longitudinal data.
Pai-Yi Chiu, Hsi-Hsien Chou, Chih-Li Lin, Hsin-Hua Li, Tzu-Yu Chen, Hong-Ming Chen, Hsin-Te Chang   +6 more
doaj   +1 more source

From Cell‐Derived Vesicles to Hybrid Nanovectors: Biological Membranes as Functional Blueprints for Gene Delivery

Advanced Healthcare Materials, EarlyView.
Biologically derived and hybrid nonviral nanovectors are examined as distinct but convergent design approaches. Integrating synthetic components with biologically functionalized membranes allows efficient interactions with complex cellular environments.
Clara Baldari, Claudia Leone, Gabriella Leccese, Claudia De Stradis, Alessandra Invidia, Concetta Quintarelli, Biagio De Angelis, Franco Locatelli, Giuseppe Gigli, Gabriele Maiorano, Ilaria Elena Palamà   +10 more
wiley   +1 more source

Combined data from LDL composition and size measurement are compatible with a discoid particle shape

Journal of Lipid Research, 2004
The size of LDL is usually reported as particle diameter, with the implicit assumption that it is a spherical particle. On the other hand, data obtained by cryoelectron microscopy and crystallographic analysis suggest that LDL shape may be discoid.
Tom Teerlink, Peter G. Scheffer, Stephan J.L. Bakker, Robert J. Heine   +3 more
doaj   +1 more source

Insights Into PCSK9, Low-Density Lipoprotein Receptor, and Low-Density Lipoprotein Cholesterol Metabolism [PDF]

Circulation, 2013
The identification of PCSK9 in 20031 has resulted in substantial revision to previous knowledge regarding cholesterol homeostasis, provided new insights into low-density lipoprotein (LDL) metabolism and LDL receptor (LDLR) function, and presented a new compelling therapeutic target to reduce LDL cholesterol (LDL-C). PCSK9 is a serine protease expressed
Evan A, Stein, Frederick J, Raal
openaire   +2 more sources

A Chemical Framework for Engineering Extracellular Vesicles’ Biointerface to Advance Precision Therapeutics

Advanced Materials, EarlyView.
Extracellular vesicles (EVs) are cell‐derived nanoparticles that mediate intercellular communication through their dynamic biointerfaces. Owing to their intrinsic biological functions, EVs have emerged as promising platforms for biomedical applications.
Leila Pourtalebi Jahromi, Felix Geng, Jan‐Noël Frenzke, Gregor Fuhrmann   +3 more
wiley   +1 more source

Design and intermediate results of the Lower Extremity Arterial Disease Event Reduction (LEADER)* trial of bezafibrate in men with lower extremity arterial disease [ISRCTN4119421]. [PDF]

, 2001
BACKGROUND: Raised levels of both triglycerides and fibrinogen, each of which are reduced by bezafibrate, may contribute to lower extremity arterial disease (LEAD).
Thomas W Meade, Meade Thomas W, Meade, Thomas W, For the British Medical Research Council General Practice Resear   +3 more
core   +1 more source