Results 221 to 230 of about 10,282,441 (287)

Combating Inflammation and Promoting Anabolism in Osteoarthritic Cartilage Defect With an MMP13‐Sensing Dual‐Drug Scaffold

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a widespread degenerative joint condition marked by progressive cartilage breakdown, and a chronic inflammatory microenvironment, where conventional therapies largely fail to halt disease progression. To address this unmet need, an intra‐articularly implantable, disease‐responsive scaffold was developed for combinatorial
Zhen Zhang, Bangheng Liu, Yulei Mu, Huiqun Zhou, Liang Ma, Chenjie Xu, Dong‐An Wang   +6 more
wiley   +1 more source

Enhancing buccal mucosa graft healing in urethroplasty: unraveling the molecular effects of two distinct therapies: low-dose radiation and low-intensity shockwave therapy. [PDF]

J Transl Med
de Oliveira PS, Vala IS, Rocha F, Leite RB, Faísca P, de Oliveira P, Pina F, Poli E, Diegues I, Ministro A, Santos SCR.   +10 more
europepmc   +1 more source

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source

Preliminary Study of Spontaneous Micronuclei and Hematology Profile of Workers Exposed to Low-Dose Radiation. [PDF]

Asian Pac J Cancer Prev
Lusiyanti Y, Tetriana D, Suvifan VA, Kisnanto T, Yusuf D, Budiantari CT, Surniyantoro HNE, Basri IKH, Purnami S.   +8 more
europepmc   +1 more source

Targeted Restoration of the Microbial Tryptophan Oxidative Pathway Ameliorates Autism‐Like Behavioral and Synaptic Deficits

Advanced Science, EarlyView.
ABSTRACT Autism Spectrum Disorder (ASD) is associated with gut microbiota dysbiosis, yet the contribution of specific microbial metabolic pathways remains unclear. Reanalysis of a public ASD cohort revealed reduced functional potential in microbial tryptophan oxidative metabolism.
Rui Guo, Caian He, Xiao Xiao, Jingmeng Li, Zilong Zhang, Ying He, Chuanchuan Wang, Jiale Zhao, Jun Gong, Jiarui Liang, Tian Yuan, Haiting Sun, Xuebo Liu, Chao Gao, Zhigang Liu   +14 more
wiley   +1 more source

Low-dose radiation and malathion co-exposure instigates long-term neurological sequelae and synergistic disruption of lipid homeostasis and energy metabolism in the hippocampus. [PDF]

Sci Rep
Narasimhamurthy RK, Venkidesh BS, Dsouza HS, Joshi MB, Murali TS, Kabekkodu SP, Rao BSS, Mumbrekar KD.   +7 more
europepmc   +1 more source

UDP‐Glucose‐6‐Dehydrogenase Mediated O‐GlcNAcylation of Tight Junction Protein 1 Suppresses Metastasis in Renal Cell Carcinoma

Advanced Science, EarlyView.
Our research unveiled a regulatory paradigm wherein TRIM25 orchestrates the ubiquitin‐mediated degradation of UGDH. UGDH modulates the protein stability of TJP1 by regulating O‐GlcNAcylation levels, effectively impeding the metastasis of ccRCC. Our insights elevate UGDH to a pivotal biomarker and tumor suppressor, marking the first demonstration that ...
Xiaolin Chen, Yuhang Bao, Tao Liu, Jianhui Qiu, Yuanyuan Ma, Zedan Zhang, Chuandong Wang, Ruiyi Deng, Zheng Song, Tianyi He, Haode Liu, Jingcheng Zhou, Yizhou Wang, Kan Gong   +13 more
wiley   +1 more source

Low-dose radiation by radiopharmaceutical therapy enhances GD2 <i>TRAC</i>-CAR T cell efficacy in localized neuroblastoma. [PDF]

Sci Adv
Sodji QH, Shea A, Cappabianca D, Forsberg MH, Eickhoff JC, Idrissou MB, Ollendorff AS, Kwon O, Ong IM, Hernandez R, Weichert J, Bednarz BP, Saha K, Sondel PM, Capitini CM, Morris ZS.   +15 more
europepmc   +1 more source

Integrative Multi‐Omics Analysis Reveals a Mitochondrial–Immune Axis Associated With Neoadjuvant Chemotherapy Response in High‐Grade Serous Ovarian Cancer

Advanced Science, EarlyView.
Integrative multi‐omics analysis delineates a mitochondrial–immune axis governing neoadjuvant chemotherapy response in high‐grade serous ovarian cancer. Immune‐active tumors exhibit enhanced B‐cell infiltration and favorable sensitivity, whereas metabolically rewired tumors display oxidative phosphorylation dependency and resistance.
Wei Jiang, Yi Wang, Xiaohang Lu, Qianlan Yao, Libing Xiang, Xu Cai, Xiaoyu Tu, Shaoxian Tang, Ying Xu, Yufan Cheng, Liming Shen, Huijuan Yang   +11 more
wiley   +1 more source

Enhancing immunotherapy efficacy with synergistic low-dose radiation in metastatic melanoma: current insights and prospects. [PDF]

J Exp Clin Cancer Res
Rafiq Z, Kang M, Barsoumian HB, Manzar GS, Hu Y, Leuschner C, Huang A, Masrorpour F, Lu W, Puebla-Osorio N, Welsh JW.   +10 more
europepmc   +1 more source