Results 191 to 200 of about 17,769,272 (338)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Pulsed Low-Dose-Rate Chemoradiation Induces Stromal Reprogramming in Pancreatic CAF-Generated ECM: Quantification by the HOST-Factor. [PDF]

Gastro Hep Adv
Franco-Barraza J, Dmitrieva M, Luong T, Egleston BL, Raghavan K, Wong JK, Vendramini-Costa DB, Francescone R, Gardiner JC, Handorf E, Dolskii A, Reddy SS, Meyer JE, Cukierman E.   +13 more
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Investigation of Normal Tissue Toxicity in Pulsed Low Dose Rate Radiotherapy. [PDF]

Cancers (Basel)
Aslmarand SM, Dos Santos T, Yang DM, Cvetkovic D, Chen L, Ma CC.   +5 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Cumulative Low-Dose-Rate Radiation Induces Oxidative Stress, Apoptosis, and Fibrosis in Mouse Testis. [PDF]

Antioxidants (Basel)
Kim EJ, Prayoga AH, Ha J, Kang DG, Yang J, Kang S, Kim JM, Ahn B, Cao DL, Yun SP, Lee BH, Kim JS, Kang D.   +12 more
europepmc   +1 more source

High dose rate versus low dose rate intracavity brachytherapy for locally advanced uterine cervix cancer.

Cochrane Database of Systematic Reviews, 2014
Rui-Feng Liu, Xiao-Hu Wang, Jin-Hui Tian, Ke-Hu Yang, Jun Wang, Lei Jiang, Xiang-Yong Hao   +6 more
semanticscholar   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Nonprostate Cancer Deaths Best Predict Long-Term Survival in Men Aged ≤59 Years Treated With Low Dose Rate Brachytherapy With or Without Supplemental Therapies: A Mandate for Health Enhancement. [PDF]

Adv Radiat Oncol
Orio P, Mirić G, Galbreath R, Moningi S, Fiano R, Wallner K, King M.   +6 more
europepmc   +1 more source

Low-Dose Rate Brachytherapy [PDF]

, 2020
openaire   +1 more source