Results 171 to 180 of about 9,693,841 (256)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Low doses of ozone alleviate cardiomyocyte ferroptosis induced by hypoxia-reoxygenation injury via the AMPK-mTOR pathway. [PDF]

Eur J Med Res
Ding Y, Hong T.
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Editorial: Research on low dose ionizing radiation health effects

Frontiers in Public Health
Jelena Pajic, Mirta Milic, Vladimir Jurisic, Volodymyr Vinnikov   +3 more
doaj   +1 more source

Levilactobacillus brevis 47f: Bioadaptation to Low Doses of Xenobiotics in Aquaculture. [PDF]

Biology (Basel)
Reznikova D, Kochetkov N, Vatlin A, Nikiforov-Nikishin D, Galanova O, Klimuk A, Smorodinskaya S, Matyushkina D, Kovalenko A, Butenko I, Marsova M, Danilenko V.   +11 more
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

EXPRESSION OF CONCERN: Aberrant Overexpression of FOXM1 Transcription Factor Plays a Critical Role in Lung Carcinogenesis Induced by Low Doses of Arsenic. [PDF]

Mol Carcinog
europepmc   +1 more source

Randomised controlled trial comparing low doses of aspirin in the prevention of pre-eclampsia (ASAPP): a study protocol. [PDF]

BMJ Open
Khander A, Matthews K, Christos P, Thomas C, Alam T, Alcus C, Bush L, Edusei E, August P, Malha L.   +9 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Low doses of cannabis extract ameliorate non-motor symptoms of Parkinson's disease patients: a case series. [PDF]

Front Hum Neurosci
Ruver-Martins AC, Martinez IAR, Holla VG, de Souza BL, da Silva EG, Novoa DMA, Souza-Silva E, Araujo FS, Prediger RD, do Nascimento FP.   +9 more
europepmc   +1 more source