Results 101 to 110 of about 32,070 (302)
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Natural and sail-displaced doubly-symmetric Lagrange point orbits for polar coverage [PDF]
, 2012 This paper proposes the use of doubly-symmetric, eight-shaped orbits in the circular restricted three-body problem for continuous coverage of the high-latitude regions of the Earth. These orbits, for a range of amplitudes, spend a large fraction of their
McInnes, Colin +3 more
core +1 more source
Design of Space Target Surveillance Constellation Based on Simulation Comparison Method
SensorsAiming at the requirement of space situational awareness on the full-domain and all-time coverage capability of low Earth orbit space targets and focusing on the design of a space-based space target awareness system, a space target awareness ...
Qinying Hu, Desheng Liu, Ziwei Dong
doaj +1 more source
Standalone GPS L1 C/A Receiver for Lunar Missions
Sensors, 2016 Global Navigation Satellite Systems (GNSSs) were originally introduced to provide positioning and timing services for terrestrial Earth users. However, space users increasingly rely on GNSS for spacecraft navigation and other science applications at ...
Vincenzo Capuano +7 more
doaj +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Low-thrust trajectories design for the European Student Moon Orbiter mission [PDF]
, 2007 The following paper presents the mission analysis studies performed for the phase A of the solar electric propulsion option of the European Student Moon Orbiter (ESMO) mission. ESMO is scheduled to be launched in 2011, as an auxiliary payload on board of
Colombo, Camilla +5 more
core
Survey of Low Earth Orbit Satellite Communication Network Routing Technology
天地一体化信息网络, 2022 Low earth orbit satellite communication network is an important part of the internet of everything era, but the characteristics of satellite constellation topology such as high dynamic, limited heterogeneous resources and unbalanced network service ...
Shuang ZHENG, Xing ZHANG, Wenbo WANG
doaj +2 more sources
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Time-optimal Earth–Mars transfer using nuclear electric propulsion
Nuclear Engineering and TechnologyThis study focuses on the time-optimal end-to-end transfer trajectory between Earth and Mars using a low-thrust nuclear electric propulsion (NEP) system.
Su-Jin Choi, Morgan Choi
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source