Results 111 to 120 of about 32,070 (302)

Sun-synchronous highly elliptical orbits using low-thrust propulsion [PDF]

, 2013
Due to restrictions within the current architecture of the global observing system (GOS), space-based remote sensing of Earth suffers from an acute data-deficit over the critical polar-regions. Currently, observation of high-latitude regions is conducted
Macdonald, Malcolm, Anderson, Pamela
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Analytical sun synchronous low-thrust manoeuvres [PDF]

, 2012
Article describes analytical sun synchronous low-thrust ...
Stephanie Y. Docherty, Macdonald, Malcolm, Malcolm Macdonald, Docherty, Stephanie, Docherty, Stephanie Y.; id_orcid   +4 more
core   +1 more source

The detection of ultra-relativistic electrons in low Earth orbit

Journal of Space Weather and Space Climate, 2018
Aims. To better understand the radiation environment in low Earth orbit (LEO), the analysis of in-situ observations of a variety of particles, at different atmospheric heights, and in a wide range of energies, is needed. Methods.
Katsiyannis Athanassios C., Dominique Marie, Pierrard Viviane, Rosson Graciela Lopez, Keyser Johan De, Berghmans David, Kruglanski Michel, Dammasch Ingolf E., Donder Erwin De   +8 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Collision Avoidance Operations for LEO Satellites Controlled by GSOC [PDF]

, 2010
The ever increasing population of objects in the near Earth environment has created growing concerns among satellite owners and control centers about the safety of their missions.
Kiehling, Reinhard, Aida, Saika, Kirschner, Michael, Wermuth, Martin   +3 more
core  

Bulk plasma properties at geosynchronous orbit. [PDF]

, 2005
We present a comprehensive study of plasma properties at geosynchronous orbit for electron and ion energies between ∼1 eV and ∼45 keV, between 1990 and 2001.
Liemohn, M. W., Zhang, J. C., Denton, M. H., Denton, Michael H., Korth, H., Thomsen, M. F., Lynch, S.   +6 more
core   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Analytical model for the propagation of small debris objects clouds after fragmentations [PDF]

, 2015
Current debris evolutionary models usually neglect fragments smaller than 10 cm because of the high computational effort they add to the simulation. However, small-debris objects can also be dangerous to operational satellites.
Colombo, Camilla, Lewis, Hugh G.; id_orcid, Letizia, Francesca, Lewis, Hugh G.   +3 more
core   +1 more source