Results 51 to 60 of about 220,920 (303)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Extension of earth orbits using low-thrust propulsion [PDF]

, 2010
The primary motivation for the utilization of space for environmental science, and in-particular Earth Observation, is the unique vantage point which a spacecraft can provide.
Anderson, Pamela, Macdonald, M.
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Very Low Earth Orbit Constellations for Earth Observation [PDF]

, 2022
Very Low Earth Orbits (VLEOs), those below 450 km, present a number of benefits and challenges for the development and operation of Earth observation spacecraft at both the system and mission level. This paper examines the design of constellations of satellites for operation in VLEO for Earth observation considering both system and mission level trade ...
Crisp, Nicholas H., Mcgrath, Ciara N., Roberts, Peter C. E., Edmondson, Steve, Haigh, Sarah J., Holmes, Brandon E. A., Macario Rojas, Alejandro, Oiko, Vitor T. A., Sinpetru, Luciana A., Smith, Katharine L., et al.   +10 more
openaire   +3 more sources

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Fused Low-Earth-Orbit GNSS

IEEE Transactions on Aerospace and Electronic Systems
Traditional Global Navigation Satellite System (GNSS) immunity to interference may be approaching a practical performance ceiling. Greater gains are possible outside traditional GNSS orbits and spectrum. GNSS from low Earth orbit (LEO) has long been viewed as promising but expensive, requiring large constellations for rapid navigation solutions.
Peter A. Iannucci, Todd E. Humphreys
openaire   +2 more sources

Innovative observing strategy and orbit determination for Low Earth Orbit Space Debris

, 2011
We present the results of a large scale simulation, reproducing the behavior of a data center for the build-up and maintenance of a complete catalog of space debris in the upper part of the low Earth orbits region (LEO).
A. Milani, A. Rossi, Africano, Bowell, Chesley, D. Farnocchia, Escobal, F. Bernardi, Farnocchia, Fujimoto, Gauss, Gronchi, Johnson, Kessler, L. Dimare, Milani, Milani, Milani, Milani, Milani, Milani, Milani, Rossi, Roy, Schildknecht, Tommei, Wiedemann   +26 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Solving Complex Low Earth Orbit-to-Geostationary Earth Orbit Transfer Problems Using Uniform Trigonometrization Method

Aerospace
Low-thrust orbit transfer problems are central to reducing mission costs and enabling cleaner, more efficient space travel. However, they remain difficult to solve using mathematically superior indirect methods of optimization.
Jackson T. Hurley, Kshitij Mall, Zhenbo Wang   +2 more
doaj   +1 more source