Results 101 to 110 of about 13,400,617 (291)

Low flow tubes [PDF]

, 1963
A study on low flow in tubes indicates that the below normal coolant flow is due to an abnormality in the rear hardware. It is suggested that reaming the rear Parker fittings on the tubes and subsequently inspecting the venturi gauges is an good solution.
openaire   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Flow induced viscoelasticity in fractures

, 2016
The behaviour of viscoelastic surfactant solutions under pressure driven flow in fractures is studied with particle image velocimetry. We demonstrate that flow is selectively retarded in larger conduits and we zoom in to smaller scales in order to ...
van der Plas, B.A., Golombok, M.
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Priapisme a bas debit : resultats du traitement chirurgical sur la fonction erectile a Abidjan- Cote d’Ivoire de 2018 a 2022

African Urology
Introduction : Le priapisme à bas débit ou priapisme veineux se définit comme étant une érection anormalement prolongée (au-delà de 3 à 4heures), irréductible, parfois douloureuse, survenant après l’orgasme ou en l’absence de tout désir ou stimulation ...
C Issoufou, A Fofana, GAP Gnabro, A Drabo, KMA Konan, NF Kramo, B Kouamé   +6 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Water Availability and Precipitation Indicators in the Muriaé River Basin, Southeast Brazil

Hydrology
This study investigated the relationship between precipitation indicators and water availability in the Muriaé River Basin (MRB), Southeast Brazil, using rainfall and streamflow series from 1961 to 2020. Monthly mean precipitation (MMP), the total annual
Eduardo Cochrane Novo, Monica de Aquino Galeano Massera da Hora, José Paulo Soares de Azevedo   +2 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source