Results 61 to 70 of about 1,204,933 (307)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

HIGH AND LOW FREQUENCY OSCILLATIONS IN DRUG EPIDEMICS [PDF]

International Journal of Bifurcation and Chaos, 2006
We extend the two-dimensional model of drug use introduced in [Behrens et al., 1999, 2000, 2002] by considering two additional states that represent in more detail newly initiated ("light") users' response to the drug experience. Those who dislike the drug quickly "quit" and briefly suppress initiation by others.
J. P. Caulkins, GRAGNANI, ALESSANDRA, G. Feichtinger, G. Tragler   +3 more
openaire   +3 more sources

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source

Self-Oscillation Multicarrier Light Source Based on Recirculating Frequency Shift Loop

IEEE Photonics Journal, 2021
A novel scheme of self-oscillation multicarrier light source based on recirculating frequency shift loop (RFSL) is proposed and experimentally demonstrated in this paper.
Long Zhang, Zhaoying Wang, Quan Yuan, Jinxin Jiang, Lai Wen, Lipei Song, Chunfeng Ge   +6 more
doaj   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Multiple DC Modulation Coordination Strategies Based on Transient Energy Function and Deep Deterministic Policy Gradient Algorithm

Applied Sciences
Ultra-low-frequency oscillation (ULFO) is a new problem of frequency stability in asynchronous network back-end power networks. The negative damping provided by hydropower units is the direct cause of ultra-low-frequency oscillation, and DC modulation is
Chao Xing, Mingqun Liu, Junzhen Peng, Xueke Wang, Yuhong Wang, Zongsheng Zheng, Shilin Gao, Jianquan Liao   +7 more
doaj   +1 more source

Research on the Hydrodynamic Performance of a Vertical Axis Current Turbine with Forced Oscillation

Energies, 2018
For a current turbine fixed on a floating platform, the wave-induced motion responses of the platform change the hydrodynamic performance of the current turbine.
Yong Ma, Chao Hu, Yulong Li, Rui Deng
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

An Active Oscillation Compensation Method to Mitigate High-Frequency Harmonic Instability and Low-Frequency Oscillation in Railway Traction Power Supply System

IEEE Access, 2018
This paper investigates the high-frequency harmonic instability (HHI) and low-frequency oscillation (LFO) phenomena in high-speed railways, and proposes an active oscillation compensation method to mitigate these HHI and LFO.
Xinyu Zhang, Jie Chen, Gang Zhang, Lei Wang, Ruichang Qiu, Zhigang Liu   +5 more
semanticscholar   +1 more source