Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Hydraulic Performance of Concrete Block Pavement under High Rainfall Intensities
Civil and Environmental Science Journal, 2019 High rainfall intensity will generate different response on the concrete block pavement (CBP) performance. A study found that larger openings of CBP did not lead more water penetrated.
Laksni Sedyowati, Eko Indah Susanti
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Shui kexue jinzhan, 2020 As one of the effective Low Impact Development measure, the grass swale has been widely used in road construction. In order to analyze the grass swale effects on the surface runoff control under different design parameters, a numerical model coupled ...
Jingming HOU +5 more
doaj +1 more source
Modelling low impact development in the Nose Creek watershed
, 2016 Increased stormwater runoff from impervious areas is a major threat to the ecological health of urban streams and the sustainability of water resources.
Cousineau, Kim
core
Challenging Inequalities: Our Early Childhood Development Sector Framework Document at a Glance
Investing in the first five years of life is essential for early childhood development (ECD) and contributes to increasing societal productivity, reducing poverty, and promoting equality.
Inter-American Development Bank
core +1 more source
The Climate and Development Challenge for Latin America and the Caribbean: Options for Climate Resilient Low Carbon Development (Summary) [PDF]
, 2012 This document is the executive summary of "The Climate and Development Challenge for Latin America and the Caribbean: Options for climate resilient low carbon development", a joint work with Economic Commission for Latin America and the Caribbean (ECLAC)
Inter-American Development Bank
core +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Report back from Sustainable Communities Summit Workshop : creating communities with a low environmental impact [PDF]
, 2012 Report is referenced by 'Comments back from the Sustainable Communities Summit Workshop : creating communities with low environmental impact'.The Sustainable Development Commission and the Department for Environment, Food & Rural Affairs’ challenging and
Great Britain. Department for Environment, Food & Rural Affairs (DEFRA) +1 more
core +2 more sources
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source