Results 111 to 120 of about 7,413,046 (314)

Low impact development technologies for mitigating climate change: Summary and prospects

open access: yesNational Science Open
Many cities are adopting low impact development (LID) technologies (a type of nature-based solution) to sustainably manage urban stormwater in future climates.
Zhang Zhonghao, Valeo Caterina
doaj   +1 more source

Champagne Seas—Foretelling the Ocean’s Future? [PDF]

open access: yes, 2009
Imagine you are an ocean researcher and you want to study the ecological impacts of ocean acidification. You know from studies carried out under controlled laboratory conditions that lowered pH can impact the physiology, growth, and development of ...
Hall-Spencer, J, Rauer, E
core   +1 more source

Biomedical Research, A Tool to Address the Health Issues that Affect African Populations. [PDF]

open access: yes, 2013
Traditionally, biomedical research endeavors in low to middle resources countries have focused on communicable diseases. However, data collected over the past 20 years by the World Health Organization (WHO) show a significant increase in the number of ...
Peprah, Emmanuel, Wonkam, Ambroise
core   +3 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Project Retrosight. Understanding the returns from cardiovascular and stroke research: Methodology Report [PDF]

open access: yes, 2011
Copyright @ 2011 RAND Europe. All rights reserved. The full text article is available via the link below.This project explores the impacts arising from cardiovascular and stroke research funded 15-20 years ago and attempts to draw out aspects of the ...
Buxton, MJ   +4 more
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Quantitative Studies of Low Impact Development Literaturein China

open access: yesRenmin Zhujiang, 2020
In the perspective of core journals, and master's and doctoral theses, and based onthe literature about low impact development (LID)retrieved from the China National KnowledgeInfrastructure (CNKI), this paper analyzes the annual publication trends ...
SUN Shiqin, HOU Jingwei
doaj  

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

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