Results 111 to 120 of about 31,660,953 (313)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Development Effectiveness Overview (DEO) 2016

open access: yes, 2017
The Development Effectiveness Overview (DEO) is an annual report produced by the IDBG to show the results and impact of its work in Latin America and the Caribbean.
Inter-American Development Bank
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

2018 Partnership Report: A Decade of Partnership

open access: yes, 2019
In 2018, partnerships were once again at the center of the Inter-American Development Bank Group’s (IDB Group) efforts to improve lives in Latin America and the Caribbean.
Inter-American Development Bank
core   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Low‐impact development boosts groundwater recharge [PDF]

open access: yesEos, Transactions American Geophysical Union, 2014
In San Francisco, as with other places, climate change is threatening to upset the balance the city has struck with the local hydrology. Precipitation in Northern California has already been increasing in winter and decreasing in summer, and projected changes to the behavior of the El Niño–Southern Oscillation hint at more of the same.
openaire   +1 more source

Challenging Inequalities: Our Early Childhood Development Sector Framework Document at a Glance

open access: yes
Investing in the first five years of life is essential for early childhood development (ECD) and contributes to increasing societal productivity, reducing poverty, and promoting equality.
Inter-American Development Bank
core   +1 more source

Impact Evaluation of the Business Development Program for Uruguay\u27s Software Industry [PDF]

open access: yes, 2010
This presentation discusses the impact of the Program for the Support of the Software Sector in Uruguay. It includes a brief summary of the project, the program outputs and outcomes, the key findings of the impact evaluation, and lessons and ...
Inter-American Development Bank
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

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