Results 61 to 70 of about 16,812,166 (316)

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

ATMOSPHERES OF LOW-MASS PLANETS: THE “BOIL-OFF” [PDF]

, 2015
We show that, for a low-mass planet that orbits its host star within a few tenths of an AU (like the majority of the Kepler planets), the atmosphere it was able to accumulate while embedded in the protoplanetary disk may not survive unscathed after the ...
J. Owen, Yanqin Wu
semanticscholar   +1 more source

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

FEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield, Torsten Kleffmann, David J. Saul, Sigurd M. Wilbanks   +3 more
wiley   +1 more source

Forged in FIRE: cusps, cores and baryons in low-mass dwarf galaxies [PDF]

, 2015
We present multiple ultrahigh resolution cosmological hydrodynamic simulations of M_★ ≃ 10^(4–6.3) M_⊙ dwarf galaxies that form within two M_(vir) = 10^(9.5–10) M_⊙ dark matter halo initial conditions.
J. Oñorbe, M. Boylan-Kolchin, J. Bullock, P. Hopkins, Duvsan Kerves, C. Faucher-Giguére, E. Quataert, N. Murray   +7 more
semanticscholar   +1 more source

A rocky planet transiting a nearby low-mass star [PDF]

Nature, 2015
M-dwarf stars—hydrogen-burning stars that are smaller than 60 per cent of the size of the Sun—are the most common class of star in our Galaxy and outnumber Sun-like stars by a ratio of 12:1.
Z. Berta-Thompson, J. Irwin, D. Charbonneau, E. Newton, J. Dittmann, N. Astudillo-Defru, X. Bonfils, M. Gillon, E. Jehin, A. Stark, B. Stalder, F. Bouchy, X. Delfosse, T. Forveille, C. Lovis, M. Mayor, V. Neves, F. Pepe, N. Santos, S. Udry, A. Wünsche   +20 more
semanticscholar   +1 more source

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

THE EVOLUTION OF THE GALAXY STELLAR MASS FUNCTION AT z = 4–8: A STEEPENING LOW-MASS-END SLOPE WITH INCREASING REDSHIFT [PDF]

, 2015
We present galaxy stellar mass functions (GSMFs) at z = 4–8 from a rest-frame ultraviolet (UV) selected sample of ∼4500 galaxies, found via photometric redshifts over an area of ∼280 arcmin2 in the Cosmic Assembly Near-infrared Deep Extragalactic Legacy ...
Mimi Song, S. Finkelstein, M. Ashby, A. Grazian, Yu Lu, C. Papovich, B. Salmon, R. Somerville, M. Dickinson, K. Duncan, S. Faber, G. Fazio, H. Ferguson, A. Fontana, Yicheng Guo, N. Hathi, Seong-Kook Lee, E. Merlin, S. Willner   +18 more
semanticscholar   +1 more source

Osteoporosis or Low Bone Mass in Older Adults: United States, 2017-2018.

NCHS data brief, 2021
Osteoporosis is the most common bone disease and is characterized by weakening of bone tissue, bone structure, and strength, and may lead to increased risk of fractures (1). Low bone mass increases the risk of developing osteoporosis (2).
Neda Sarafrazi, Edwina A. Wambogo, J. Shepherd   +2 more
semanticscholar   +1 more source