Results 191 to 200 of about 1,262,170 (343)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

open access: yesFEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl   +13 more
wiley   +1 more source

An Unsupervised Machine Learning Approach to Identify Spectral Energy Distribution Outliers: Application to the S-PLUS DR4 Data

open access: yesThe Astronomical Journal
Identification of specific stellar populations using photometry for spectroscopic follow-up is a first step to confirm and better understand their nature.
F. Quispe-Huaynasi   +15 more
doaj   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

open access: yesFEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid   +3 more
wiley   +1 more source

The rotation of low mass stars at 30 Myr in the cluster NGC 3766. [PDF]

open access: yesProc Int Astron Union, 2019
Roquette J   +6 more
europepmc   +1 more source

Low-mass neutron star nucleosynthesis — stripping scenario

open access: yesInternational Journal of Modern Physics E
This paper examines nucleosynthesis in a low-mass neutron star crust that loses mass due to accretion in a close binary system and reaching a hydrodynamically unstable configuration explodes. The r-process proceeds mainly in the inner crust. Nucleosynthesis in the outer crust is an explosive process with a sharp increase in temperature caused by an ...
A. Yu. Ignatovskiy   +2 more
openaire   +2 more sources

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

open access: yesFEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani   +6 more
wiley   +1 more source

Measuring the magnetic fields in the chromospheres of low-mass stars. [PDF]

open access: yesNat Commun
Cang T   +13 more
europepmc   +2 more sources

Red-giant Asteroseismology of Low-mass Population III Stars

open access: yesThe Astrophysical Journal
Low-mass stars from the first epoch of star formation may still persist in the Milky Way and its satellite dwarf galaxies today; however, their detection is confounded by surface pollution from interstellar accretion and internal mixing, which obscure ...
Thiago Ferreira   +3 more
doaj   +1 more source

Characterizing <i>K2</i> Candidate Planetary Systems Orbiting Low-Mass Stars IV: Updated Properties for 86 Cool Dwarfs Observed During Campaigns 1-17. [PDF]

open access: yesAstrophys J, 2019
Dressing CD   +17 more
europepmc   +1 more source

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