Results 171 to 180 of about 1,262,170 (343)
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
The Astronomical JournalM dwarfs are ubiquitous in our Galaxy, and the rate at which they host stellar companions, and the properties of these companions, provide a window into the formation and evolution of the star(s), and of any planets that they may host.
Catherine A. Clark +10 more
doaj +1 more source
Low-mass stars: Open problems all along their evolution
EPJ Web of Conferences, 2013 Although low-mass stars have a comparatively simple structure, current stellar models are far from reproducing them accurately. In light of the observational progress, in particular of asteroseismology, the deficits of the theory of stellar structure and
Heners N., Weiss A.
doaj +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Linearity of Structure Kernels in Main-sequence and Subgiant Solar-like Oscillators
The Astrophysical JournalSeismic structure inversions have been used to study the solar interior for decades. With the high-precision frequencies obtained using data from the Kepler mission, it has now become possible to study other solar-like oscillators using structure ...
Lynn Buchele +3 more
doaj +1 more source
S-process in low-mass extremely metal-poor stars
EPJ Web of Conferences, 2012 We present post-processing s-process calculations for the core He-flash of a 1M☉ star with and Z = 10−8. Our model shows neutron densities larger than 1014cm−3, resulting in the production of s-process elements. The model reproduces the C, O, Sr, and Ba
Weiss A., Serenelli A., Cruz M.A.
doaj +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
New Ultracool Companions to Nearby White Dwarfs
The Astronomical JournalWe conducted a search for new ultracool companions to nearby white dwarfs using multiple methods, including the analysis of colors and examination of images in both the optical and the infrared.
Alexia Bravo +17 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source