Results 151 to 160 of about 11,210,903 (298)

New Ultracool Companions to Nearby White Dwarfs

The Astronomical Journal
We conducted a search for new ultracool companions to nearby white dwarfs using multiple methods, including the analysis of colors and examination of images in both the optical and the infrared.
Alexia Bravo, Adam C. Schneider, Sarah Casewell, Austin Rothermich, Jacqueline K. Faherty, Jenni R. French, Thomas P. Bickle, Aaron M. Meisner, J. Davy Kirkpatrick, Marc J. Kuchner, Adam J. Burgasser, Federico Marocco, John H. Debes, Arttu Sainio, Léopold Gramaize, Frank Kiwy, Peter A. Jałowiczor, Awab Abdullahi   +17 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Demographics of M Dwarf Binary Exoplanet Hosts Discovered by TESS

The Astronomical Journal
M dwarfs have become increasingly important in the detection of exoplanets and the study of Earth-sized planets and their habitability. However, 20%–30% of M dwarfs have companions that can impact the formation and evolution of planetary systems.
Rachel A. Matson, Rebecca Gore, Steve B. Howell, David R. Ciardi, Jessie L. Christiansen, Catherine A. Clark, Ian J. M. Crossfield, Sergio B. Fajardo-Acosta, Rachel B. Fernandes, Elise Furlan, Emily A. Gilbert, Erica Gonzales, Kathryn V. Lester, Michael B. Lund, Elisabeth C. Matthews, Alex S. Polanski, Joshua E. Schlieder, Carl Ziegler   +17 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Constraining Mass Loss and Lifetimes of Low Mass, Low Metallicity AGB Stars [PDF]

, 2015
The evolution and lifetimes of thermally pulsing asymptotic giant branch (TP-AGB) stars suffer from significant uncertainties. We present a detailed framework for constraining model luminosity functions of TP-AGB stars using resolved stellar populations.
Aringer, B., Bressan, A., Dalcanton, J. J., GULLIEUSZIK, MARCO, Marigo, P., GIRARDI, Leo Alberto, Williams, B. F., Rosenfield, P., Weisz, D. R., Dolphin, A.   +9 more
core  

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source