Results 131 to 140 of about 13,442,946 (252)
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
Rotational evolution of low-mass stars at different metallicities
, 2018 A lot of efforts have been made recently in understanding the rotational evolution of low-mass stars. However, modelling stars of different clusters at different ages suggests at least slightly different chemical composition.
Charbonnel, Corinne (5300392) +7 more
core +1 more source
The Formation of Low-Mass Stars and Brown Dwarfs [PDF]
, 2014 It is estimated that ~60% of all stars (including brown dwarfs) have masses below 0.2Msun. Currently, there is no consensus on how these objects form. I will briefly review the four main theories for the formation of low-mass objects: turbulent fragmentation, ejection of protostellar embryos, disc fragmentation, and photo-erosion of prestellar cores. I
openaire +2 more sources
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
The 2D dynamics of radiative zones of low-mass stars
, 2018 Context. Helioseismology and asteroseismology allow us to probe the differential rotation deep within low-mass stars. In the solar convective envelope, the rotation varies with latitude with an equator rotating faster than the pole, which results in a ...
Mathis, Stéphane +5 more
core +1 more source
Searching for Low-mass Stars with Magnetically Induced Hyperinflated Radii
The Astrophysical JournalPrecise empirical estimates of stellar radii have revealed that the radii of certain low-mass stars are inflated relative to stellar structure predictions: the largest inflations occur in magnetically active stars.
D. J. Mullan, J. MacDonald
doaj +1 more source
Astronomy & AstrophysicsContext. The F-, G-, K-, and M-type stars are the most abundant stellar population in the Milky Way and are expected to contribute to its diffuse X-ray emission.
Zheng Xueying +17 more
doaj +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source