Results 111 to 120 of about 55,137 (312)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Red horizontal branch stars in the Galactic field: A chemical abundance survey [PDF]

, 2013
40th Liege International Astrophysical Colloquium on Ageing Low Mass Stars - From Red Giants to White Dwarfs -- JUL 09-13, 2012 -- Liege, BELGIUMA large sample survey of Galactic red horizontal-branch (RHB) stars was conducted to investigate their ...
Fo, B. -Q., Afsar, M., B.-Q. For, M. Afşar, B.-Q. Fo, Sneden, C., C. Sneden   +6 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Evolution of Mass Functions of Coeval Stars through Wind Mass Loss and Binary Interactions [PDF]

, 2015
Accurate determinations of stellar mass functions and ages of stellar populations are crucial to much of astrophysics. We analyze the evolution of stellar mass functions of coeval main-sequence stars, including all relevant aspects of single and binary ...
Schneider, F.R.N., Izzard, Robert, Izzard, R.G., Schneider, F. R. N., Mink, S. E. de, Langer, N., de Mink, S.E.   +6 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

The 2D dynamics of radiative zones of low-mass stars

, 2018
Context. Helioseismology and asteroseismology allow us to probe the differential rotation deep within low-mass stars. In the solar convective envelope, the rotation varies with latitude with an equator rotating faster than the pole, which results in a ...
Mathis, Stéphane, D. Hypolite, S. Mathis, Hypolite, Delphine, Rieutord, Michel, M. Rieutord   +5 more
core   +1 more source

The mass-loss, expansion velocities and dust production rates of carbon stars in the Magellanic Clouds [PDF]

, 2019
The properties of carbon stars in the Magellanic Clouds (MCs) and their total dust production rates are predicted by fitting their spectral energy distributions (SED) over pre-computed grids of spectra reprocessed by dust.
Van Loon
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Equilibria and oscillations of magnetised neutron stars

, 2010
We investigate equilibrium configurations and oscillation spectra of neutron stars,modelled as rotating magnetised fluid bodies in Newtonian gravity. We also explorethe idea that these model neutron stars could have dynamics analogous to rigid-bodyfree ...
Lander, Samuel Kenneth
core  

Final Evolution of a Low-Mass Star. I

The Astrophysical Journal, 1970
Low mass star evolution from helium burning to white dwarf, describing red giant and mass loss stages in ...
William K. Rose, Richard L. Smith
openaire   +1 more source