Results 91 to 100 of about 38,924 (266)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

The Variation in the Galaxy-wide Initial Mass Function for Low-mass Stars: Modeling and Observational Insights

The Astrophysical Journal
The stellar initial mass function (IMF) characterizes the mass distribution of newly formed stars in various cosmic environments, serving as a fundamental assumption in astrophysical research. Recent findings challenge the prevalent notion of a universal
Zhiqiang Yan, Jiadong Li, Pavel Kroupa, Tereza Jerabkova, Eda Gjergo, Zhi-Yu Zhang   +5 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Low-mass stars: Open problems all along their evolution

EPJ Web of Conferences, 2013
Although low-mass stars have a comparatively simple structure, current stellar models are far from reproducing them accurately. In light of the observational progress, in particular of asteroseismology, the deficits of the theory of stellar structure and
Heners N., Weiss A.
doaj   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Digging into the Interior of Hot Cores with ALMA (DIHCA). VI. The Formation of Low-mass Multiple Systems in High-mass Cluster-forming Regions

The Astrophysical Journal
Most stars form in multiple systems, with profound implications in numerous astronomical phenomena intrinsically linked to multiplicity. However, our knowledge about the process of how multiple stellar systems form is incomplete and biased toward nearby ...
Qiu-yi Luo, Patricio Sanhueza, Stella S. R. Offner, Fernando Olguin, Adam Ginsburg, Fumitaka Nakamura, Kaho Morii, Yu Cheng, Kei E. I. Tanaka, Junhao Liu, Tie Liu, Xing Lu, Qizhou Zhang, Kotomi Taniguchi, Piyali Saha, Shanghuo Li, Xiaofeng Mai   +16 more
doaj   +1 more source

Identification of the plant mitochondrial OrfX protein: A mass spectrometry approach

FEBS Letters, EarlyView.
The mitochondrial genome of plants contains an open reading frame, orfx, which encodes a rare protein that has so far escaped mass spectrometric detection. The protein resembles the c‐subunit of bacterial twin‐arginine‐motif‐dependent protein translocases (TatC).
Matthias Döring, Jan de Jonge, Hans‐Peter Braun, Nils Rugen   +3 more
wiley   +1 more source

High-resolution Elemental Abundance Measurements of Cool JWST Planet Hosts Using AutoSpecFit: An Application to the Sub-Neptune K2-18b’s Host M Dwarf

The Astrophysical Journal
We present an in-depth, high-resolution spectroscopic analysis of the M dwarf K2-18, which hosts a sub-Neptune exoplanet in its habitable zone. We show our technique to accurately normalize the observed spectrum, which is crucial for a proper spectral ...
Neda Hejazi, Ian J. M. Crossfield, Diogo Souto, Jonathan Brande, Thomas Nordlander, Emilio Marfil, Katia Cunha, David R. Coria, Zachary G. Maas, Alex S. Polanski, Natalie R. Hinkel, Joseph E. Hand   +11 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

The CHARA Array Interferometric Program on the Multiplicity of Classical Be Stars: New Detections and Orbits of Stripped Subdwarf Companions

The Astrophysical Journal
Rapid rotation and nonradial pulsations enable Be stars to build decretion disks, where the characteristic line emission forms. A major but unconstrained fraction of Be stars owe their rapid rotation to mass and angular momentum transfer in a binary. The
Robert Klement, Thomas Rivinius, Douglas R. Gies, Dietrich Baade, Antoine Mérand, John D. Monnier, Gail H. Schaefer, Cyprien Lanthermann, Narsireddy Anugu, Stefan Kraus, Tyler Gardner   +10 more
doaj   +1 more source