Results 101 to 110 of about 38,924 (266)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Linearity of Structure Kernels in Main-sequence and Subgiant Solar-like Oscillators

The Astrophysical Journal
Seismic structure inversions have been used to study the solar interior for decades. With the high-precision frequencies obtained using data from the Kepler mission, it has now become possible to study other solar-like oscillators using structure ...
Lynn Buchele, Earl P. Bellinger, Saskia Hekker, Sarbani Basu   +3 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Marginally Stable Nuclear Burning Triggered at Different Depths of the Neutron Star Surface in Low-mass X-Ray Binary 4U 1608-52

The Astrophysical Journal
We investigated the timing and spectral properties of the millihertz quasiperiodic oscillations (mHz QPOs) in the neutron star low-mass X-ray binary 4U 1608–52 using NICER observations. Our analysis reveals a correlation between the QPO frequency and its
Ming Lyu, Guobao Zhang, Mariano Méndez, Huaping Xiao   +3 more
doaj   +1 more source

The Formation of Low-Mass Stars and Brown Dwarfs [PDF]

, 2014
It is estimated that ~60% of all stars (including brown dwarfs) have masses below 0.2Msun. Currently, there is no consensus on how these objects form. I will briefly review the four main theories for the formation of low-mass objects: turbulent fragmentation, ejection of protostellar embryos, disc fragmentation, and photo-erosion of prestellar cores. I
openaire   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Disk Lifetime Distribution as a Function of the Mass of Host Star

The Astrophysical Journal
The lifetime of protoplanetary disks is a critical factor for planet formation. Although the mean disk lifetime provides an estimate of the typical period available for planet formation, it does not capture the substantial variability in individual disk ...
Susanne Pfalzner, Furkan Dincer, Nienke van der Marel, Frank W. Wagner   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

New Ultracool Companions to Nearby White Dwarfs

The Astronomical Journal
We conducted a search for new ultracool companions to nearby white dwarfs using multiple methods, including the analysis of colors and examination of images in both the optical and the infrared.
Alexia Bravo, Adam C. Schneider, Sarah Casewell, Austin Rothermich, Jacqueline K. Faherty, Jenni R. French, Thomas P. Bickle, Aaron M. Meisner, J. Davy Kirkpatrick, Marc J. Kuchner, Adam J. Burgasser, Federico Marocco, John H. Debes, Arttu Sainio, Léopold Gramaize, Frank Kiwy, Peter A. Jałowiczor, Awab Abdullahi   +17 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source