Results 121 to 130 of about 55,137 (312)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Constraining Mass Loss and Lifetimes of Low Mass, Low Metallicity AGB Stars [PDF]

, 2015
The evolution and lifetimes of thermally pulsing asymptotic giant branch (TP-AGB) stars suffer from significant uncertainties. We present a detailed framework for constraining model luminosity functions of TP-AGB stars using resolved stellar populations.
Aringer, B., Bressan, A., Dalcanton, J. J., GULLIEUSZIK, MARCO, Marigo, P., GIRARDI, Leo Alberto, Williams, B. F., Rosenfield, P., Weisz, D. R., Dolphin, A.   +9 more
core  

Nucleosynthesis in low- and intermediate-mass stars: An overview [PDF]

Tours symposium on nuclear physics III, 1998
An overview of the main phases of the evolution of low- and intermediate-mass stars is presented, and the different types of nucleosynthesis operating from the pre-main sequence up to and including the asymptotic giant branch phase described. The surface abundance modifications brought by each nucleosynthesis process is also briefly discussed.
openaire   +2 more sources

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Realistic Uncertainties for Fundamental Properties of Asteroseismic Red Giants and the Interplay between Mixing Length, Metallicity, and

The Astrophysical Journal
Asteroseismic modeling is a powerful way to derive stellar properties. However, the derived quantities are limited by built-in assumptions used in stellar models.
Yaguang Li, Timothy R. Bedding, Daniel Huber, Dennis Stello, Jennifer van Saders, Yixiao Zhou, Courtney L. Crawford, Meridith Joyce, Tanda Li, Simon J. Murphy, K. R. Sreenivas   +10 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

ε-mechanism driven pulsations in hot subdwarf stars with mixed H-He atmospheres

Open Astronomy, 2017
The ε mechanism is a self-excitation mechanism of stellar pulsations which acts in regions where nuclear burning takes place. It has been shown that the ε mechanism can excite pulsations in hot pre-horizontal branch stars before they settle into the ...
Battich Tiara, Bertolami Marcelo M. Miller, Córsico Alejandro H., Althaus Leandro G.   +3 more
doaj   +1 more source

Characterizing circumstellar disk around young stars

, 2010
The circumstellar disks play a fundamental role in star and planet formation process. Studies on circumstellar disks are generally carried on following two viable approaches: "statistical" studies, where a large samples of sources are measured to ...
Schisano, Eugenio
core  

Low-mass companions to Hyades stars

, 2005
It is now well established that a large fraction of the low-mass stars are binaries or higher order multiples. Similarly a sizable fraction have giant planets. In contrast to these, the situation for brown dwarf companions is complicated: While close
E. W. Guenther, D. B. Paulson, J. Patience, B. Macintosh, A. P. Hatzes, W. D. Cochran   +5 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source