Results 161 to 170 of about 1,262,170 (343)
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
The Astrophysical JournalThe stellar initial mass function (IMF) characterizes the mass distribution of newly formed stars in various cosmic environments, serving as a fundamental assumption in astrophysical research. Recent findings challenge the prevalent notion of a universal
Zhiqiang Yan +5 more
doaj +1 more source
A disk of dust and molecular gas around a high-mass protostar
, 2005 The processes leading to the birth of low-mass stars such as our Sun have been well studied, but the formation of high-mass (> 8 x Sun's mass) stars has heretofore remained poorly understood.
AI Sargent +36 more
core +2 more sources
Constraining Mass-Loss & Lifetimes of Low Mass, Low Metallicity AGB Stars
, 2014 5 pages, 3 figures, proceedings of the conference "Why Galaxies Care About AGB Stars III", Vienna July 28 - August 1, 2014 to appear in an upcoming ASP Conference Series ...
Rosenfield, Philip +9 more
openaire +2 more sources
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
The Astrophysical JournalWe present an in-depth, high-resolution spectroscopic analysis of the M dwarf K2-18, which hosts a sub-Neptune exoplanet in its habitable zone. We show our technique to accurately normalize the observed spectrum, which is crucial for a proper spectral ...
Neda Hejazi +11 more
doaj +1 more source
Olivier Chesneau's Work on Low Mass Stars [PDF]
EAS Publications Series, 2015 During his too short career, Olivier Chesneau pioneered the study of the circumstellar environments of low mass evolved stars using very high angular resolution techniques. He applied state of the art high angular resolution techniques, such as optical interferometry and adaptive optics imaging, to the the study of a variety of objects, from AGB stars ...
openaire +2 more sources
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
The Astrophysical JournalMost stars form in multiple systems, with profound implications in numerous astronomical phenomena intrinsically linked to multiplicity. However, our knowledge about the process of how multiple stellar systems form is incomplete and biased toward nearby ...
Qiu-yi Luo +16 more
doaj +1 more source