Results 121 to 130 of about 36,234 (283)

Analysis in the CLCN5 gene in patients with familial idiopathic low-molecular-weight proteinuria.

Nihon Shoni Jinzobyo Gakkai Zasshi, 1998
家族性特発性低分子蛋白尿症 (familial idiopathic low-molecular-weight proteinuria: FILMWP) は，低分子蛋白尿を呈する腎尿細管障害で本邦にて報告された。一方，腎結石症を伴うDent病などの3つの遺伝性腎尿細管障害が欧米で報告され，クロライドチャンネルCLCN5遺伝子の異常であることが報告された。これらの疾患には臨床上の類似性がみられるが，FILMWPでは腎不全やくる病がないことで区別される。 私達はFILMWP患者5例についてCLCN5遺伝子を解析し，一塩基挿入2例，一塩基欠失2例，ナンセンス変異1例を認めた。FILMWPの多くは本遺伝子の異常でおこると考えられ，これら4つの腎尿細管疾患は1つの疾患の亜型と考えられる ...
Hitoshi Nakazato, Shinzaburo Hattori, Junichiro Yoshimuta, Akio Furuse, Shinnyo Karashima, Tomoyasu Kawano, Tadashi Ushijima, Misako Hiramatsu, Shinichi Matsumoto, Fumio Endo, Ichiro Matsuda   +10 more
openaire   +2 more sources

Forsythiaside A Alleviates Kidney Injury and Intestinal Epithelium Dysfunction in IgA Nephropathy by Inhibiting TLR4/NF‐κB Signaling

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT IgA nephropathy (IgAN), the most common form of glomerulonephritis, is a major and growing public health issue. It results from intestinal barrier dysfunction that leads to mesangial deposition of pathogenic galactose‐deficient IgA1 (Gd‐IgA1) and renal inflammation.
Meng‐Si Li, Kai Liu
wiley   +1 more source

Chronic, Environmentally Relevant PM2.5 Exposure Exacerbates Metabolic Dysfunction‐Associated Steatotic Liver Disease and Early‐Stage Renal Dysfunction in a Rodent Model

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT While epidemiological studies link fine particulate matter (PM2.5) exposure to metabolic dysfunction‐associated steatotic liver disease (MASLD) and renal dysfunction, a translational gap exists, as most animal models utilize acute, high‐dose exposures that poorly reflect chronic, moderate‐level human scenarios.
Yi‐Siao Chen, Hugo You‐Hsien Lin, Chien‐Tzu Lin, Si‐Hua Huang, Ming‐Lun Yeh, Ming‐Lung Yu, Jin‐Ching Lee, Yao‐Chi Chung, Wei‐Ming Li, Ching‐Chia Li, Shiu‐Feng Huang, Chia‐Hung Yen   +11 more
wiley   +1 more source

Case Report: Early acute kidney failure in an 11-year-old boy with Dent disease type 1

Frontiers in Pediatrics
Dent disease type 1 (Dent 1) is a rare X-linked genetic condition which impacts kidney function and is caused by pathogenic variants in CLCN5.
Nicolette Murphey, Craig Authement, Paul Hillman, Samhar I. Al-Akash, Kate Richardson   +4 more
doaj   +1 more source

Dent disease

Zdravniški Vestnik, 2017
Dent disease is an x-linked disorder of proximal renal tubular dysfunction that occurs almost exclusively in males. It is characterized by significant, mostly low molecular weight proteinuria, hypercalciuria, nephrocalcinosis, nephrolithiasis, and ...
Rina R Rus, Kristina Vogrin
doaj  

Early onset preeclampsia is characterized by altered placental lipid metabolism and a premature increase in circulating FABP4 [PDF]

, 2010
Preeclampsia is a pregnancy-associated disorder that manifests as a sudden increase in maternal blood pressure accompanied by proteinuria. Because the placenta is a key organ in preeclampsia, we used proteomic and lipidomic analyses to compare placentae ...
Aaron Booy, Delfina Siroen, Gilles Lajoie, Jennifer Ballard, Nicholas Carruthers, Victor H. Han   +5 more
core   +1 more source

Current Status of Kidney Xenotransplantation in Basic Research

Organ Medicine, EarlyView.
Kidney xenotransplantation is a potential solution to the organ shortage for end‐stage kidney disease. This review systematically elaborates on the application advances of donor pig gene editing technologies, the molecular mechanisms and regulatory strategies of xenogeneic immune rejection, and the optimization approaches of immune compatibility ...
Yu Luo, Bingzhuo Liu, Weijie Lai
wiley   +1 more source

Safety Evaluation of an Aqueous Root and Leaf Extract of Ashwagandha (Withania somnifera)

Phytotherapy Research, EarlyView.
Sensoril, an aqueous root and leaf extract of ashwagandha showed no evidence of mutagenicity in the in vitro Ames assay, was negative in the in vitro micronucleus, in vivo mammalian bone marrow chromosome aberration assays, and was well tolerated in the rat at up to 4000 mg/kg BW/day when administered orally for a period of 90 days. The data from these
Mukesh Summan, Candace L. Doepker, Gregory P. Brorby   +2 more
wiley   +1 more source

Impaired Hearing and Systolic Blood Pressure as Potential Markers of Cerebral Infarction After Eclampsia: A Cross‐Sectional Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective Eclampsia is associated with short‐ and long‐term neurological deficits. Identifying which women may be at risk is important. Magnetic resonance imaging shows an incidence of 30%–40% of subclinical cerebral infarcts among women with eclampsia. A simple screening tool would be useful to identify at‐risk women.
Lina Bergman, Henrik Imberg, Eduard Langenegger, Ashley Moodley, Richard Pitcher, Stephanie Griffith‐Richards, Karl Bergman, Roxanne Hastie, Stephen Tong, Susan P. Walker, Johan Wikström, Catherine Cluver   +11 more
wiley   +1 more source

The effect of dietary cadmium on kidney function in cats : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Animal Science at Massey University, Palmerston North, New Zealand [PDF]

, 2017
Due to the requirement for meat in feline diets, this study aimed to investigate the potential effects on kidney function in cats of cadmium accumulation in meat products due to pasture management practices.
Anderson, Jeanette M J
core