Results 61 to 70 of about 862,186 (311)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Compact conversion and cyclostationary noise modelling of pn junction diodes in low-injection - Part II: Discussion [PDF]
, 2004 Starting from the compact conversion and cyclostationary pn diode noise model presented in the companion paper, we present an extensive validation based on comparisons with physics-based numerical simulations.
Bonani, Fabrizio +2 more
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Low noise high performance 50nm T-gate metamorphic HEMT with cut-off frequency fT of 440 GHz for millimeterwave imaging receivers applications [PDF]
, 2005 The 50 nm m-HEMT exhibits extremely high f<sub>T</sub>, of 440GHz, low F<sub>min</sub> of 0.7 dB, associated gain of 13 dB at 26 GHz with an exceptionally high Id of 200 mA/mm and gm of 950 ms/mm at low noise biased ...
H. McLelland +9 more
core +1 more source
A Two-Step A/D Conversion and Column Self-Calibration Technique for Low Noise CMOS Image Sensors
Sensors, 2014 In this paper, a 120 frames per second (fps) low noise CMOS Image Sensor (CIS) based on a Two-Step Single Slope ADC (TS SS ADC) and column self-calibration technique is proposed.
Jaeyoung Bae +4 more
doaj +1 more source
A low‐noise current‐reused CMOS active inductor by exploiting Gm‐boosting technique
IET Microwaves, Antennas & Propagation, 2021 This work introduces a new low‐noise current‐reused CMOS active inductor (AI) based on Gyrator‐C configuration. In the proposed AI, a simple common‐source amplifier is utilised for boosting effective Gm and improving noise performance of the AI.
Abdollah Sabbaghi, Emad Ebrahimi
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Remote SensingMeasurement of lightning current plays a critical role in the field of atmospheric electricity. Traditionally, Rogowski coils or low-resistance shunts were employed for measuring lightning currents in the range from several amperes up to several hundreds
Shaoyang Wang +5 more
doaj +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source