Results 71 to 80 of about 862,186 (311)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Trailing Edge Noise Reduction by Passive and Active Flow Controls [PDF]

, 2014
This paper presents the results on the use of porous metal foams (passive control) and dielectric barrier surface plasma actuations (active control) for the reduction of vortex shedding tonal noises from the nonflat plate type trailing edge serration in ...
Kim, JH, Tze Pei Chong, Vathylakis, A, Laith Al-Sadawi, Al-Sadawi, L, Alexandros Vathylakis, Jung Hoon Kim, Chong, TP   +7 more
core   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Polarization Mode Noise in Ultra-Low Drift Phase Reference Distribution System over Fiber Network [PDF]

, 2005
The impact of polarization mode noise on the temporal drift of a delivered analogue phase reference signal through an optical fiber network is studied.
Shillue, William P., Huggard, Peter G., Davies, Phil A., Shen, Pengbo, Gomes, Nathan J.   +4 more
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Design of CMOS Charge-sensitive Amplifier for Coaxial High Purity Germanium Detector

Yuanzineng kexue jishu
High purity germanium detectors play an increasingly significant role in particle physics and astrophysics, particularly in low-background radiation measurement experiments, due to their exceptional energy resolution, high detection efficiency.
LIU Zhan, HE Gaokui, LIU Haifeng
doaj   +1 more source

Free Space Optic Receiver with Strongly Overlapped Photodetectors’ Field of View

Applied Sciences, 2019
In this study, we designed a mobile free space optic receiver that uses several photodetectors to provide omnidirectional receiving capability. Assuming only one transmitter, it is a receiver which builds a single input multiple output optical channel ...
Karel Witas, Jan Nedoma
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

A multi-filter system for speech enhancement under low signal-to-noise ratios

, 2009
In this paper, the problem of deteriorating performance of speech recognition under very low signal-to-noise ratios (SNR) is considered. In particular, for a given pre-trained speech recognizer and for a finite set of speech commands, we show that ...
Nordholm, Sven, Yiu, K.F.C., Low, SY, Chan, KY, Nordholm, S., Low, S.Y., Nordholm, S, Chan, Kit Yan, Yiu, KFC, Chan, K., Yiu, Ka Fai, Low, Siow Yong, Chan, K.Y., Low, Siow   +13 more
core   +1 more source

Spatial Smoothing for Diffusion Tensor Imaging with low Signal to Noise Ratios [PDF]

, 2003
Though low signal to noise ratio (SNR) experiments in DTI give key information about tracking and anisotropy, e.g. by measurements with very small voxel sizes, due to the complicated impact of thermal noise such experiments are up to now seldom analysed.
Prigarin, Sergej M., Pütz, Benno, Hahn, Klaus R., Prigarin, Sergej, Hahn, Klaus   +4 more
core   +1 more source