Results 51 to 60 of about 23,755,136 (238)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

LP-MAB: Improving the Energy Efficiency of LoRaWAN Using a Reinforcement-Learning-Based Adaptive Configuration Algorithm

Sensors, 2023
In the Internet of Things (IoT), Low-Power Wide-Area Networks (LPWANs) are designed to provide low energy consumption while maintaining a long communications’ range for End Devices (EDs).
Benyamin Teymuri, Reza Serati, Nikolaos Athanasios Anagnostopoulos, Mehdi Rasti   +3 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

A distribution level wide area monitoring system for the electric power grid-FNET/GridEye [PDF]

, 2017
The wide area monitoring system (WAMS) is considered a pivotal component of future electric power grids. As a pilot WAMS that has been operated for more than a decade, the frequency monitoring network FNET/GridEye makes use of hundreds of global ...
Dao Zhou, Liu, Yilu, Yao, Wenxuan, Yong Liu, Ling Wu, Hesen Liu, Liu, Hesen, Yi Cui, Shutang You, Wu, Ling, Yilu Liu, Zhou, Dao, Wenxuan Yao, Jiecheng Zhao, You, Shutang, Liu, Yong, Cui, Yi, Zhao, Jiecheng   +17 more
core   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Qualitative assessment of low power wide area network protocols and their security aspects: A umbrella review

Measurement. Digitalization
There are currently many communication options in the Internet of Things, even in particular areas such as constrained and battery-powered devices, such as Low Power Wide Area Networks.
W.R. Bezerra, L.M. Bezerra, Carlos B. Westphall   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A novel wireless visual sensor network protocol based on LoRa modulation

International Journal of Distributed Sensor Networks, 2018
At present, aiming at complexity of topology and limited network coverage for wireless visual sensor networks so that partial application cannot be implemented. Considering this situation, a novel low-power wide area network protocol is proposed with the
Chunlei Fan, Qun Ding
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source