Results 61 to 70 of about 221,156 (291)

Validation of a tool for estimating clinician recognition of ARDS using data from the international LUNG SAFE study.

PLOS Digital Health, 2023
Under-recognition of acute respiratory distress syndrome (ARDS) by clinicians is an important barrier to adoption of evidence-based practices such as low tidal volume ventilation. The burden created by the COVID-19 pandemic makes it even more critical to
Meagan A Bechel, Fabiana Madotto, Adam R Pah, Giacomo Bellani, John G Laffey, Tài Pham, Luís A Nunes Amaral, Curtis H Weiss   +7 more
doaj   +1 more source

Low Tidal Volume Ventilation Use in Acute Respiratory Distress Syndrome* [PDF]

Critical Care Medicine, 2016
Objective: Low tidal volume ventilation lowers mortality in the acute respiratory distress syndrome. Previous studies reported poor low tidal volume ventilation implementation. We sought to determine the rate, quality, and predictors of low tidal volume ventilation use.
Curtis H, Weiss, David W, Baker, Shayna, Weiner, Meagan, Bechel, Margaret, Ragland, Alfred, Rademaker, Bing Bing, Weitner, Abha, Agrawal, Richard G, Wunderink, Stephen D, Persell   +9 more
openaire   +2 more sources

Bound and unbound substructures in Galaxy-scale Dark Matter haloes [PDF]

, 2010
We analyse the coarse-grained phase-space structure of the six Galaxy-scale dark matter haloes of the Aquarius Project using a state-of-the-art 6D substructure finder.
Aubert, Boylan-Kolchin, Cole, Davis, Diemand, Diemand, Diemand, Diemand, Ghigna, Governato, Kamionkowski, Kamionkowski, Kim, Klypin, Knollmann, Kuhlen, Maciejewski, Maciejewski, Mark Vogelsberger, Michal Maciejewski, Moore, Neyrinck, Sharma, Sharma, Simon D. M. White, Springel, Springel, Stoehr, Vogelsberger, Vogelsberger, Volker Springel, Wang   +31 more
core   +1 more source

F‐Box and Leucine‐Rich Repeat Protein 4 (FBXL4) Maintains Sarcomere Integrity and Cardiac Function by Enhancing K48‐Linked Ubiquitinated Degradation of Profilin‐1 (PFN1)

Advanced Science, EarlyView.
Schematic diagram depicting the proposed signaling mechanisms underlying the effects of FBXL4 in the setting of cardiac hypertrophy. Under hypertrophic stimulation, cardiomyocytes‐specific overexpression FBXL4 maintains sarcomere integrity and cardiac function by enhancing K48‐linked ubiquitinated degradation of PFN1 at the K70 site.
Xingda Li, Xueqi He, Xinyuan Hao, Yu Zhang, Xin Zhao, Shuang Wang, Zhenru Wang, Haonan Du, Hongda Li, Lian Yi, Zhimin Du, Weijie Du   +11 more
wiley   +1 more source

Driving pressure is not associated with mortality in mechanically ventilated patients without ARDS

Critical Care, 2019
Background In patients with acute respiratory distress syndrome (ARDS), low tidal volume ventilation has been associated with reduced mortality. Driving pressure (tidal volume normalized to respiratory system compliance) may be an even stronger predictor
Michael J. Lanspa, Ithan D. Peltan, Jason R. Jacobs, Jeffrey S. Sorensen, Lori Carpenter, Jeffrey P. Ferraro, Samuel M. Brown, Jay G. Berry, Raj Srivastava, Colin K. Grissom   +9 more
doaj   +1 more source

COVENT-Tester: A low-cost, open source ventilator tester

HardwareX, 2021
COVENT-Tester (COVID-19 VENTilator Tester) is a low-cost and open source ventilator tester developed to calibrate the output of medical ventilators, including tidal volume, inspiratory pressure, and oxygen concentration. Currently, there are several open-
Tomy Abuzairi, Ahli Irfan, Basari
doaj   +1 more source

Targeted Extracellular Vesicles Deliver Asiaticoside to Inhibit AURKB/DRP1‐Mediated Mitochondrial Fission and Attenuate Hypertrophic Scar Formation

Advanced Science, EarlyView.
Hypertrophic scar formation is driven by excessive mitochondrial fission in wound macrophages, which we discover is governed by a novel AURKB‐DRP1(Ser616) axis. The study develops a targeted therapy using cRGD‐decorated extracellular vesicles to deliver the natural compound Asiaticoside specifically to macrophages.
Luyu Li, Chenli Si, Xue Wang, Xiaojin Wu, Ying Shang, Shengfang Ge, Yong Wang, Yong Zuo, Zhen Zhang   +8 more
wiley   +1 more source

Estimating the Causal Effect of Lower Tidal Volume Ventilation on Survival in Patients with Acute Lung Injury [PDF]

, 2008
Acute lung injury (ALI) is a condition characterized by acute onset of severe hypoxemia and bliateral pulmonary infiltrates. ALI patients typically require mechanical ventilation in an intensive care unit.
Brower, Roy, Needham, Dale, Scharfstein, Daniel, Wang, Weiwei   +3 more
core   +1 more source

Respiratory‐Limbic Coupling via a Thalamic Circuit Alleviates Anxiety

Advanced Science, EarlyView.
This study delineates a conserved preBötCGlu→PVT→CeA circuit that gates anxiety and respiration. Activation of this circuit is anxiolytic and respiratory‐stabilizing, while its inhibition has the opposite effect. Mechanistically, PVT exerts its anxiolytic action via a disinhibitory microcircuit: its inputs preferentially target CeL GABAergic neurons ...
Shangyu Bi, Xiaoyi Wang, Huichun Luo, Ziteng Yue, Tianjiao Deng, Yuhang Liu, Xinxin Chen, Jianxu Zhao, Luo Shi, Ning Ma, Lingyan Mao, Jing Ding, Jiwen Xu, Ti‐Fei Yuan, Sheng Wang, Fang Yuan   +15 more
wiley   +1 more source

Intraoperative Protective Mechanical Ventilation in Dogs: A Randomized Clinical Trial

Frontiers in Veterinary Science, 2022
ObjectiveTo evaluate gas exchange, respiratory mechanics, and hemodynamic impact of mechanical ventilation with low tidal volume (VT) in dogs with the use of positive end-expiratory pressure (PEEP) or preceded by alveolar recruitment maneuver (ARM).Study
Renata R. Rodrigues, Aline M. Ambrósio, Aline M. Engbruch, Lucas A. Gonçalves, Paula A. Villela, Ana F. Sanchez, Denise T. Fantoni   +6 more
doaj   +1 more source