Results 61 to 70 of about 6,618,541 (298)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Monetary Policy, Asset-price Bubbles and the Zero Lower Bound [PDF]
We use a simple model of a closed economy to study the recommendations of monetary policy-makers attempting to respond optimally to an asset-price bubble whose stochastic properties they understand. We focus on the impact which the zero lower bound (ZLB)
Tim Robinson, Andrew Stone
core +2 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Efficient optimization of the Held–Karp lower bound
Open Journal of Mathematical Optimization, 2021 Given a weighted undirected graph $G=(V,E)$, the Held–Karp lower bound for the Traveling Salesman Problem (TSP) is obtained by selecting an arbitrary vertex $\bar{p} \in V$, by computing a minimum cost tree spanning $V \backslash \lbrace \bar{p}\rbrace $
Righini, Giovanni
doaj +1 more source
On lower bounds for the L_2-discrepancy
Journal of Complexity, 2010 The L_2-discrepancy measures the irregularity of the distribution of a finite point set. In this note we prove lower bounds for the L_2 discrepancy of arbitrary N-point sets. Our main focus is on the two-dimensional case. Asymptotic upper and lower estimates of the L_2-discrepancy in dimension 2 are well-known and are of the sharp order sqrt(log N ...
Aicke Hinrichs, Lev Markhasin
openaire +3 more sources
Lower bounds for the bandwidth problem
Computers & Operations Research, 2021 The Bandwidth Problem seeks for a simultaneous permutation of the rows and columns of the adjacency matrix of a graph such that all nonzero entries are as close as possible to the main diagonal. This work focuses on investigating novel approaches to obtain lower bounds for the bandwidth problem.
Franz Rendl +2 more
openaire +5 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Bayesian Cramér-Rao Lower Bound for Magnetic Field-Based Localization
IEEE Access, 2022 In this paper, we show how to analyze the achievable position accuracy of magnetic localization based on Bayesian Cramér-Rao lower bounds and how to account for deterministic inputs in the bound.
Benjamin Siebler +2 more
doaj +1 more source