Results 41 to 50 of about 899,895 (356)

Does repetitive task training improve functional activity after stroke? A Cochrane systematic review and meta-analysis. [PDF]

, 2010
Repetitive task training resulted in modest improvement across a range of lower limb outcome measures, but not upper limb outcome measures. Training may be sufficient to have a small impact on activities of daily living.
Forster, Anne, French, Beverley, Langhorne, Peter, Leathley, Michael John, McAdam, Joanna, Price, Christopher, Sutton, Chris J, Thomas, Lois Helene, Walker, Andrew, Watkins, Caroline Leigh   +9 more
core   +2 more sources

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source

THE USE OF PHYSICAL ACTIVITY OUTCOMES IN REHABILITATION INTERVENTIONS FOR LOWER LIMB AMPUTEES: A SYSTEMATIC REVIEW

Canadian Prosthetics & Orthotics Journal, 2020
BACKGROUND: Interventions which have focused on improving the physical activity of individuals with lower limb amputation can be mostly categorized into behavioural-based and prosthetic-based interventions.
Alexander Jamieson, Laura Murray, Arjan Buis   +2 more
doaj   +1 more source

Novel mutations expand the clinical spectrum of DYNC1H1-associated spinal muscular atrophy [PDF]

, 2015
OBJECTIVE To expand the clinical phenotype of autosomal dominant congenital spinal muscular atrophy with lower extremity predominance (SMA-LED) due to mutations in the dynein, cytoplasmic 1, heavy chain 1 (DYNC1H1) gene.
Al-Lozi, Muhammad T, Baas, Frank, Baloh, Robert H, Benatar, Michael, Calissano, Mattia, Chong, W K Kling, Cirak, Sebahattin, Connolly, Anne M, de Goede, Christian G E L, De Visser, Marianne, Fallon, Penny, Foley, A Reghan, Hadjikoumi, Irene, Hafezparast, Majid, Harms, Matthew B, Klein, Andrea, Mansour, Sahar, Manzur, Adnan Y, Martínez Arroyo, Amaia, Mcwilliam, Catherine, Mercuri, Eugenio, Muntoni, Francesco, Nixon, John, Overweg-Plandsoen, W C G Truus, Phadke, Rahul, Pitt, Matthew, Reilly, Mary M, Robb, Stephanie, Rodriguez Sanz, Aida, Rossor, Alexander M, Scoto, Mariacristina, Sewry, Caroline, Taylor, J Paul, Yang, Michele   +33 more
core   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Prototype Multifunctional Device for Contraction Exercises of Joints and Muscles of the Lower Limb [PDF]

Transactions of the VŠB-Technical University of Ostrava, Mechanical Series, 2013
In the article Authors are showing the endurance test of the prototype multifunctional device for contraction exercises of joints and strengthening muscles.
Pawel JURECZKO, Damian GĄSIOREK, Michal BACHORZ, Lukasz JUSZYŃSKI   +3 more
doaj   +1 more source

Major Limb Amputations: A Tertiary Hospital Experience in Northwestern Tanzania. [PDF]

, 2012
Major limb amputation is reported to be a major but preventable public health problem that is associated with profound economic, social and psychological effects on the patient and family especially in developing countries where the prosthetic services ...
Chalya, Phillipo L, Chandika, Alphonce B, Dass, Ramesh M, Gilyoma, Japhet M, Mabula, Joseph B, Mbelenge, Nkinda, Ngayomela, Isdori H   +6 more
core   +3 more sources

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Lower Limb Exoskeleton Sensors: State-of-the-Art

Sensors, 2022
Due to the ever-increasing proportion of older people in the total population and the growing awareness of the importance of protecting workers against physical overload during long-time hard work, the idea of supporting exoskeletons progressed from high-
Slávka Neťuková, Martin Bejtic, Christiane Malá, Lucie Horáková, Patrik Kutílek, Jan Kauler, Radim Krupička   +6 more
doaj   +1 more source

Method and apparatus for simulating gravitational forces on a living organism [PDF]

, 1983
A method and apparatus for simulating gravitational forces on a living organism wherein a series of negative pressures are externally applied to successive length-wise sections of a lower limb of the organism.
Thornton, W. E.
core   +1 more source