Results 141 to 150 of about 4,939,312 (268)

Glofitamab in combination with immunochemotherapy in patients with relapsed/refractory B‐cell non‐Hodgkin lymphoma: Phase 1b dose‐escalation study

open access: yesBritish Journal of Haematology, EarlyView.
Summary Glofitamab was investigated with obinutuzumab/rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone (G/R‐CHOP) in patients with relapsed/refractory B‐cell non‐Hodgkin lymphoma (B‐NHL) who had ≥1 prior obinutuzumab/rituximab‐containing therapy (NCT03467373). The primary end‐point was to determine the optimal biological dose of
William Townsend   +16 more
wiley   +1 more source

Genesis of crystalline crust and lithosphere of ancient platforms according to data on the hot heterogeneous accretion of the Earth

open access: yesЛитосфера, 2017
Compositions of gneisses from the Early Precambrian crystalline complexes of the Aldan shield and of mantle xenoliths from kimberlites plot along the magmatic fractionation trends.
Vladimir S. Shkodzinskii
doaj  

Mineralogy of the deep lower mantle in the presence of H2O. [PDF]

open access: yesNatl Sci Rev, 2021
Hu Q   +7 more
europepmc   +1 more source

Dispersal, source and glass chemistry of a third tephra unit within Iceland's Settlement Layer

open access: yesBoreas, EarlyView.
Tephra layers may be studied to understand the dynamics and sequence of past explosive volcanism. In Iceland, the distinctive Settlement Layer (AD ~877) underlies almost all archaeological evidence for the Norse Settlement and is preserved in soils across Iceland and as cryptotephra overseas.
Conner A. G. Morison   +3 more
wiley   +1 more source

Linking rates of slab sinking to long-term lower mantle flow and mixing [PDF]

open access: yes
Numerical models of Earth's mantle dynamics that aim to comply with a variety of surface observations and/or modern mantle structure, still predict a widely varying vigour of mantle flow which governs the long-term evolution of mantle structure and ...
Spakman, Wim   +3 more
core  

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown   +2 more
wiley   +1 more source

Bruton tyrosine kinase inhibitors and cardiovascular adverse events

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Bruton tyrosine kinase inhibitors (BTKi) have transformed the management of chronic lymphocytic leukaemia and other B‐cell malignancies, yet their therapeutic benefit is tempered by clinically relevant cardiovascular toxicities (predominantly atrial fibrillation, hypertension, bleeding and ventricular arrhythmias).
Massimiliano Camilli   +4 more
wiley   +1 more source

Rheology of the lower mantle: an alternative review. [PDF]

open access: yesProg Earth Planet Sci
Cordier P, Van Orman J, Carrez P.
europepmc   +1 more source

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