Results 161 to 170 of about 4,939,312 (268)

A guide to transcriptional cyclin‐dependent kinases in cancer

The FEBS Journal, EarlyView.
Transcriptional cyclin‐dependent‐kinases (tCDKs) facilitate gene expression by promoting RNA polymerase II (RNAPII) progression through discrete phases of the transcription cycle. Aberrant tCDK activity is detectable in different human cancers, thereby contributing to de‐regulated gene expression programs that drive oncogenic phenotypes.
Jennifer R. Devlin, Salla Kyheröinen, Ricky W. Johnstone   +2 more
wiley   +1 more source

Lower-mantle iron heterogeneity constrained by the electrical conductivity of Al-bearing bridgmanite. [PDF]

Sci Adv
Han K, Özaydın S, Fei H, Man L, Wang F, Chanyshev A, Withers AC, Grayver A, Katsura T.   +8 more
europepmc   +1 more source

Contrasting Food Web Dynamics Across Oceanographic Boundaries in Subarctic Pelagic Ecosystems

Fisheries Oceanography, EarlyView.
ABSTRACT Understanding the structure of pelagic food webs across multiple trophic levels is critical for elucidating species interactions, energy flow, and anthropogenic impacts on production. This study presents a comprehensive analysis of the eastern North Pacific pelagic food webs, focusing on the Gulf of Alaska (GoA) during late winter of 2019.
Genyffer C. Troina, Evgeny A. Pakhomov, Laurie Weitkamp, Brian P. V. Hunt   +3 more
wiley   +1 more source

Onset of slab mantle melting in Earth's lower mantle: Evidence from ferropericlase in superdeep diamonds. [PDF]

Sci Adv
Ni P, Shirey SB, Walter MJ, Czas J, Novella D, Nestola F, Kueter N, Smith EM, Stachel T, Pearson DG, Steele A, Gardner LL, Jacobsen SD, Harte B, Harris JW, Shahar A.   +15 more
europepmc   +1 more source

Comparison of intestinal histopathological changes following teclistamab, BCMA‐directed CAR T, CD19‐directed CAR T and rituximab therapies

Histopathology, EarlyView.
This is a retrospective review of intestinal tract biopsies from patients treated with various cellular immunotherapies (BCMA and CD19‐directed CAR T, teclistamab and rituximab therapies). We found distinct but overlapping histologic patterns across treatment groups, with lamina propria plasma cell depletion, crypt apoptotic bodies and active ...
Olivia J Leung, Esther Baranov, Isairis Peralta Valerio, Robin Collingwood, Natalie Respond, Don Siegel, Pooja Devi, Kristen M. Stashek   +7 more
wiley   +1 more source

Evidence for the stability of ultrahydrous stishovite in Earth's lower mantle. [PDF]

Proc Natl Acad Sci U S A, 2020
Lin Y, Hu Q, Meng Y, Walter M, Mao HK.
europepmc   +1 more source

ICSH Guidance on Bone Marrow Examination and Reporting

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Examination of the bone marrow (BM) remains fundamental to the diagnosis, classification, prognostication, and monitoring of hematolymphoid and other disorders affecting blood cell production. Since publication of the International Council for Standardization in Haematology (ICSH) guideline in 2008, advances in diagnostic technologies, disease
Wendy N. Erber, Alexandar Tzankov, Olga Pozdnyakova, Hiromichi Matsushita, Gina Zini, Leonie Saft, on behalf of the International Council for Standardization in Haematology   +6 more
wiley   +1 more source

The role of pyrope garnet in water transport into the topmost lower mantle. [PDF]

Natl Sci Rev
Chen L, Zhao X, Xu C, Li X, Zhang X, Feng B, Hu K, Liu B, Liu Z, Xu W.   +9 more
europepmc   +1 more source

Xenon iron oxides predicted as potential Xe hosts in Earth's lower mantle. [PDF]

Nat Commun, 2020
Peng F, Song X, Liu C, Li Q, Miao M, Chen C, Ma Y.   +6 more
europepmc   +1 more source

The ‘Geopolitical Commission’: 40 Years in the Making?

JCMS: Journal of Common Market Studies, EarlyView.
Abstract In 2019, European Commission President Ursula von der Leyen promised MEPs she would deliver a ‘Geopolitical Commission’ during the five years of her term in office, unbeknown that the COVID‐19 pandemic and the Russian invasion of Ukraine were around the corner.
Robert Kissack
wiley   +1 more source