Results 41 to 50 of about 4,939,312 (268)

Epidemiological Survey and Genomic Insights Into Ostreid Herpesvirus 1 Transmission in the Blood Clam Anadara broughtonii in China (2019–2025)

Animal Research and One Health, EarlyView.
Seven‐year surveillance reveals a cold‐adapted OsHV‐1 lineage in blood clams, with disease onset at 13°C—3–5°C lower than in oysters—and identifies asymptomatic carriers and facility effluent as key transmission routes. ABSTRACT Ostreid herpesvirus 1 (OsHV‐1) poses a major threat to bivalve aquaculture, but its impact on blood clams (Anadara ...
Xiang Zhang, Bowen Huang, Tao Yu, Jingli Wang, Maole Wei, Huigang Kang, Chongming Wang, Changming Bai   +7 more
wiley   +1 more source

Integrated Clinical and Proteomic Profiling of CD19 Chimeric Antigen Receptor T Cell Therapy in Progressive Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective To characterize the clinical, immunologic, and proteomic changes associated with CD19 chimeric antigen receptor T cell therapy in patients with progressive systemic sclerosis (SSc). Methods Patients with progressive SSc received CD19 chimeric antigen receptor (CAR)‐T cell therapy and were observed longitudinally for safety, clinical efficacy,
Chenhan Jia, Wanyi Lin, Zhangyi Zhao, Fenglin Wu, Chaoyu Gu, Yuankai Sun, Zhe Ding, Chang Wei, Xinyu Li, Cuiwei Xie, Peng Xia, Zhen Xia, Xuesong Liu, Shaoying Yang, Chunyan Zhang, Hanlin Yin, Liangjing Lu   +16 more
wiley   +1 more source

Seismic visibility of carbonated subducted oceanic crust in the lower mantle

Communications Earth & Environment
Seismological studies have previously detected abundant scatterers in the lower mantle, potentially linked to long-term slab subduction, and petrology studies suggest carbonates can be sequestrated within the oceanic crust and transported into the lower ...
Yajie Zhao, Xin Deng, Wenzhong Wang, Zhongqing Wu, Ye Yuan   +4 more
doaj   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Dislocation creep may control bridgmanite deformation in the Earth’s lower mantle

Communications Earth & Environment
Seismic anisotropy in the Earth’s lower mantle, particularly around subduction zones, is commonly attributed to deformation by dislocation creep, yet much of the lower mantle appears nearly isotropic.
Longli Guan, Daisuke Yamazaki, Noriyoshi Tsujino, Yuji Higo, Sho Kakizawa, Xiang Wu, Junfeng Zhang   +6 more
doaj   +1 more source

Development of Lattice‐Preferred Orientations of MgO Periclase From Strain Rate Controlled Shear Deformation Experiments Under Pressure up to 120 GPa

Geophysical Research Letters, 2022
The seismic anisotropy observed in Earth's lowermost mantle (D″ layer) is thought to originate from the lattice‐preferred orientation (LPO) of mantle materials induced by plastic deformation.
Yohan Park, Shintaro Azuma, Keishi Okazaki, Kentaro Uesugi, Masahiro Yasutake, Yu Nishihara, Ryuichi Nomura   +6 more
doaj   +1 more source

Stability of magnesiowüstite in Earth's lower mantle [PDF]

Proceedings of the National Academy of Sciences, 2003
Magnesiowüstite [(Mg,Fe)O] is the second most abundant mineral of Earth's lower mantle. Understanding its stability under lower mantle conditions is crucial for interpreting the physical and chemical properties of the whole Earth. Previous studies in an externally heated diamond anvil cell suggested that magnesiowüstites decompose ...
Jung-Fu, Lin, Dion L, Heinz, Ho-kwang, Mao, Russell J, Hemley, James M, Devine, Jie, Li, Guoyin, Shen   +6 more
openaire   +2 more sources

Regulatory harmonization: Evolution, globalization and future directions

British Journal of Clinical Pharmacology, EarlyView.
Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm, Elaine Y. L. Blair, Christine Y. Lu   +2 more
wiley   +1 more source

Tertiary-Quaternary intra-plate magmatism in Europe and its relationship to mantle dynamics [PDF]

, 2006
Anorogenic intra-plate magmatism was widespread in Europe from early Tertiary to Recent times, extending west to east from Spain to Bulgaria, and south to north from Sicily to northern Germany. Magmatism is spatially and temporally associated with Alpine-
Wilson, M., Downes, Hilary
core   +5 more sources

Earth's Lower Mantle Predominated by Ferric Iron‐Rich Bridgmanite Inferred From High Pressure Elasticity Measurements

Geophysical Research Letters
The absence of sound‐velocity data spanning the entire lower mantle pressures for (Fe, Al)‐bearing bridgmanite impedes direct comparisons with seismic wave observations, leaving the chemistry of the lower mantle unresolved.
P. Saha, M. Murakami, N. Miyajima
doaj   +1 more source